Zonegran and Vicodin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zonegran (zonisamide) and Vicodin (acetaminophen; hydrocodone bitartrate). Common drug interactions include chest pain among females and depression among males.

The phase IV clinical study analyzes what interactions people have when they take Zonegran and Vicodin. It is created by eHealthMe based on reports of 74 people who take the same drugs from the FDA, and is updated regularly.

What is Zonegran?

Zonegran has active ingredients of zonisamide. It is often used in epilepsy. eHealthMe is studying from 6,211 Zonegran users. Check the latest studies of Zonegran.

What is Vicodin?

Vicodin has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 63,357 Vicodin users. Check the latest studies of Vicodin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

74 people who take Zonegran and Vicodin together, and have interactions are studied.

What are the common drug interactions of Zonegran and Vicodin, by gender? *:

female:

Chest pain
Contusion (a type of hematoma of tissue in which capillaries)
Palpitations (feelings or sensations that your heart is pounding or racing)
Cough
Fall
Fatigue (feeling of tiredness)
Flushing (the warm, red condition of human skin)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Muscle spasms (muscle contraction)
Pyelonephritis (inflammation of kidney caused by bacteria)

male:

Depression
Abnormal dreams
Visual disturbance
Pulmonary oedema (fluid accumulation in the lungs)
Gun shot wound
Fall
Adrenal haemorrhage (bleeding into the adrenal gland)
Bradycardia (abnormally slow heart action)
Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)
Blood calcium decreased

What are the common drug interactions of Zonegran and Vicodin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Fear
Injury
Pulmonary embolism (blockage of the main artery of the lung)

20-29:

Cardiac disorder
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Pregnancy
Pulmonary embolism (blockage of the main artery of the lung)
Type 1 diabetes mellitus
Cardiac failure congestive
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Erythema (redness of the skin)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Joint injury

30-39:

Suicidal ideation
Blood bicarbonate decreased
Blood calcium decreased
Blood glucose increased
Blood potassium decreased
Blood pressure decreased
Heart rate increased
Pco2 decreased
Visceral congestion (blocking of internal organs of the body)
Blood chloride increased

40-49:

Dizziness
Nausea (feeling of having an urge to vomit)
Balance disorder
Chest pain
Fatigue (feeling of tiredness)
Hyperhidrosis (abnormally increased sweating)
Insomnia (sleeplessness)
Lumbar spinal stenosis (a medical condition in which the spinal canal narrows and compresses the spinal cord and nerves at the level of the lumbar bone)
Mood swings (an extreme or rapid change in mood)
Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)

50-59:

Dyspnoea (difficult or laboured respiration)
Cardiac disorder
Contusion (a type of hematoma of tissue in which capillaries)
Death
Dizziness
Drug ineffective
Palpitations (feelings or sensations that your heart is pounding or racing)
Skin burning sensation
Adverse event
Anxiety

60+:

Drug hypersensitivity
Arteriosclerosis (thickening and hardening of arteries)
Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Musculoskeletal chest pain (pain in chest muscle or nerve or bones)
Oedema peripheral (superficial swelling)
Peripheral vascular disorder
Syncope (loss of consciousness with an inability to maintain postural tone)
Anaemia (lack of blood)
Bone pain
Communication disorder (speech and language disorder)

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 11 people, 14.86%
Migraine (headache): 8 people, 10.81%
Insomnia (sleeplessness): 7 people, 9.46%
Headache (pain in head): 6 people, 8.11%
High Blood Pressure: 5 people, 6.76%
Depression: 5 people, 6.76%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 5.41%
Back Pain: 4 people, 5.41%

* Approximation only. Some reports may have incomplete information.

Do you take Zonegran and Vicodin?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously