Zonegran and Zelnorm drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zonegran (zonisamide) and Zelnorm (tegaserod maleate). Common drug interactions include abdominal pain among females and alanine aminotransferase increased among males.

The phase IV clinical study analyzes what interactions people have when they take Zonegran and Zelnorm. It is created by eHealthMe based on reports of 25 people who take the same drugs from the FDA, and is updated regularly.

What is Zonegran?

Zonegran has active ingredients of zonisamide. It is often used in epilepsy. eHealthMe is studying from 6,211 Zonegran users. Check the latest studies of Zonegran.

What is Zelnorm?

Zelnorm has active ingredients of tegaserod maleate. eHealthMe is studying from 7,261 Zelnorm users. Check the latest studies of Zelnorm.

On Jul, 25, 2026

25 people who take Zonegran and Zelnorm together, and have interactions are studied.

What are the common drug interactions of Zonegran and Zelnorm, by gender? *:

female:

Abdominal pain
Respiratory failure (inadequate gas exchange by the respiratory system)
Cardiac failure congestive
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Nausea (feeling of having an urge to vomit)
Neuropathy peripheral (surface nerve damage)
Pyrexia (fever)
Vomiting
Abdominal tenderness
Blood creatinine increased

male:

Alanine aminotransferase increased
Aspartate aminotransferase increased
Diabetic retinopathy (damage to the retina caused by complications of diabetes)
Ketoacidosis (high concentrations of ketone bodies in blood)
Pancreatitis (inflammation of pancreas)
Stent placement
Vision blurred
Bile duct obstruction (blockage in the tubes that carry bile from the liver to the gallbladder)
Diabetes mellitus inadequate control
Pancreatitis acute (sudden inflammation of pancreas)

What are the common drug interactions of Zonegran and Zelnorm, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Cardiac disorder
Depression
Suicidal ideation
Type 1 diabetes mellitus
Cardiac failure congestive
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Joint injury
Thrombosis (formation of a blood clot inside a blood vessel)
Viral cardiomyopathy (weakness in the muscle of the heart due to viral infection)

30-39:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Abdominal pain
Anaemia (lack of blood)
Bacteraemia (presence of bacteria in the blood)
Calculus urinary (stone in urinary system)
Cardiomyopathy (weakening of the heart muscle)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetic gastroparesis (paralysis of the muscles of the stomach caused by diabetes)
Diabetic nephropathy (diabetic kidney disease)

40-49:

Neuropathy peripheral (surface nerve damage)
Abdominal pain
Abdominal tenderness
Blood creatinine increased
Cardiac failure congestive
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Colitis ischaemic (due to infection of intestine impaired blood supply to colon)
Decreased appetite
Haemoglobin decreased
Hypercholesterolaemia (high levels of cholesterol in the blood)

50-59:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Confusional state
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Hypoaesthesia (reduced sense of touch or sensation)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)

60+:

Alanine aminotransferase increased
Aspartate aminotransferase increased
Bile duct stone
Blood bilirubin increased
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Pancreatic carcinoma (pancreatic cancer)
Stent placement
Bile duct obstruction (blockage in the tubes that carry bile from the liver to the gallbladder)

What are the existing conditions these people have? *

Constipation: 4 people, 16.00%
Impaired Gastric Emptying: 3 people, 12.00%
High Blood Pressure: 3 people, 12.00%
Back Pain: 3 people, 12.00%
Neuralgia (pain in one or more nerves): 3 people, 12.00%
Nausea (feeling of having an urge to vomit): 3 people, 12.00%
Insomnia (sleeplessness): 3 people, 12.00%
High Blood Cholesterol: 3 people, 12.00%
Anaemia (lack of blood): 2 people, 8.00%
Depression: 2 people, 8.00%

* Approximation only. Some reports may have incomplete information.

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