Zonisamide and Epinephrine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zonisamide (zonisamide) and Epinephrine (epinephrine). Common drug interactions include hyperhidrosis among females and cerebrovascular accident among males.

The phase IV clinical study analyzes what interactions people have when they take Zonisamide and Epinephrine. It is created by eHealthMe based on reports of 49 people who take the same drugs from the FDA, and is updated regularly.

What is Zonisamide?

Zonisamide has active ingredients of zonisamide. It is often used in epilepsy. eHealthMe is studying from 11,445 Zonisamide users. Check the latest studies of Zonisamide.

What is Epinephrine?

Epinephrine has active ingredients of epinephrine. It is often used in asthma. eHealthMe is studying from 21,290 Epinephrine users. Check the latest studies of Epinephrine.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

49 people who take Zonisamide and Epinephrine together, and have interactions are studied.

Zonisamide and Epinephrine drug interactions.

What are the common drug interactions of Zonisamide and Epinephrine, by gender? *:

female:

Hyperhidrosis (abnormally increased sweating)
Hypoxia (low oxygen in tissues)
Lethargy (tiredness)
Pallor
Alanine aminotransferase increased
Ankle fracture
Aspartate aminotransferase increased
Headache (pain in head)
Pyrexia (fever)
Pneumonia

male:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Dyspnoea (difficult or laboured respiration)
Sepsis (a severe blood infection that can lead to organ failure and death)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Nephrolithiasis (calculi in the kidneys)
Urinary tract infection
Face injury
Fall
Bacterial infection
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)

What are the common drug interactions of Zonisamide and Epinephrine, by age (0-1 to 60+)? *:

0-1:

Kawasaki's disease (an autoimmune disease in which the medium-sized blood vessels throughout the body become inflamed)
Pyrexia (fever)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Alanine aminotransferase increased
Aspartate aminotransferase increased
Febrile convulsion (a convulsion associated with a significant rise in body temperature)

2-9:

n/a

10-19:

Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Oral mucosal blistering (mouth ulcer)
Rash
Rash vesicular (rash with a small bubble)
Urticaria (rash of round, red welts on the skin that itch intensely)

20-29:

n/a

30-39:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Sepsis (a severe blood infection that can lead to organ failure and death)
Weight decreased

40-49:

Headache (pain in head)
Dizziness
Fatigue (feeling of tiredness)
Pruritus (severe itching of the skin)
Rash
Ankle fracture
Chest discomfort
Chills (felling of cold)
Fall
Haemorrhage (bleeding)

50-59:

Dyspnoea (difficult or laboured respiration)
Hyperhidrosis (abnormally increased sweating)
Hypoxia (low oxygen in tissues)
Lethargy (tiredness)
Pallor
Urticaria (rash of round, red welts on the skin that itch intensely)
Vomiting
Post procedural complication
Post procedural infection
Swelling face

60+:

Oedema (fluid collection in tissue)
Headache (pain in head)
Pelvic pain
Post procedural complication
Pulmonary mass
Weight increased
Abdominal distension
Abnormal faeces (abnormal stool)
Fatigue (feeling of tiredness)
Fluid retention (an abnormal accumulation of fluid in the blood)

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 15 people, 30.61%
Sedation: 5 people, 10.20%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 5 people, 10.20%
Hypokalemia (low potassium): 5 people, 10.20%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 10.20%
Gastritis (inflammation of stomach): 5 people, 10.20%
Pemphigoid (tense blisters on the skin): 4 people, 8.16%
Immunodeficiency: 4 people, 8.16%

* Approximation only. Some reports may have incomplete information.

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