Zonisamide and Nucynta drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zonisamide (zonisamide) and Nucynta (tapentadol hydrochloride). Common drug interactions include pruritus among females and gastrooesophageal reflux disease among males.

The phase IV clinical study analyzes what interactions people have when they take Zonisamide and Nucynta. It is created by eHealthMe based on reports of 30 people who take the same drugs from the FDA, and is updated regularly.

What is Zonisamide?

Zonisamide has active ingredients of zonisamide. It is often used in epilepsy. eHealthMe is studying from 11,445 Zonisamide users. Check the latest studies of Zonisamide.

What is Nucynta?

Nucynta has active ingredients of tapentadol hydrochloride. It is often used in pain. eHealthMe is studying from 31,818 Nucynta users. Check the latest studies of Nucynta.

On Jul, 17, 2026

30 people who take Zonisamide and Nucynta together, and have interactions are studied.

Zonisamide and Nucynta drug interactions.

What are the common drug interactions of Zonisamide and Nucynta, by gender? *:

female:

Pruritus (severe itching of the skin)
Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Blood pressure increased
Drug hypersensitivity
Fall
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Rash
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Sinus congestion (blockage of sinus)

male:

Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Nephrolithiasis (calculi in the kidneys)
Renal failure (kidney dysfunction)

What are the common drug interactions of Zonisamide and Nucynta, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Death
Hypoaesthesia (reduced sense of touch or sensation)
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Muscle spasticity (tight or stiff muscles and an inability to control those muscles)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)

40-49:

Chronic kidney disease
Nephrolithiasis (calculi in the kidneys)
Renal failure (kidney dysfunction)
Renal injury (kidney injury)

50-59:

Anxiety
Foot fracture
Body temperature increased
Burning sensation
Contusion (a type of hematoma of tissue in which capillaries)
Discomfort
Fatigue (feeling of tiredness)
Gastrointestinal infection (infection of stomach and intestine)
Headache (pain in head)
Impaired healing

60+:

n/a

What are the existing conditions these people have? *

Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 6 people, 20.00%
Sleep Disorder: 5 people, 16.67%
Fibromyalgia (a long-term condition which causes pain all over the body): 5 people, 16.67%
Thrombosis (formation of a blood clot inside a blood vessel): 4 people, 13.33%
Migraine (headache): 3 people, 10.00%
Insomnia (sleeplessness): 3 people, 10.00%
Immunodeficiency: 3 people, 10.00%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 6.67%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 6.67%
Immunodeficiency Common Variable: 2 people, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Zonisamide and Nucynta?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously