Zonisamide and Nuedexta drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zonisamide (zonisamide) and Nuedexta (dextromethorphan hydrobromide; quinidine sulfate). Common drug interactions include memory impairment among females.

The phase IV clinical study analyzes what interactions people have when they take Zonisamide and Nuedexta. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Zonisamide?

Zonisamide has active ingredients of zonisamide. It is often used in epilepsy. eHealthMe is studying from 11,445 Zonisamide users. Check the latest studies of Zonisamide.

What is Nuedexta?

Nuedexta has active ingredients of dextromethorphan hydrobromide; quinidine sulfate. eHealthMe is studying from 3,781 Nuedexta users. Check the latest studies of Nuedexta.

On Aug, 01, 2026

11 people who take Zonisamide and Nuedexta together, and have interactions are studied.

Zonisamide and Nuedexta drug interactions.

What are the common drug interactions of Zonisamide and Nuedexta, by gender? *:

female:

Memory impairment
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Restless legs syndrome (a powerful urge to move your legs)
Speech disorder
Urinary tract infection
Urosepsis (secondary infection that occurs when a urinary tract infection spreads to the bloodstream)
Vertigo
Vitamin d deficiency
Aphasia (damage to the parts of the brain that control language)
Arthralgia (joint pain)

male:

n/a

What are the common drug interactions of Zonisamide and Nuedexta, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Malaise (a feeling of general discomfort or uneasiness)

50-59:

n/a

60+:

Urinary tract infection
Urosepsis (secondary infection that occurs when a urinary tract infection spreads to the bloodstream)
Confusional state
Epistaxis (bleed from the nose)
Fatigue (feeling of tiredness)
Memory impairment
Quality of life decreased
Somnolence (a state of near-sleep, a strong desire for sleep)
Trance

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 9 people, 81.82%
Hypersensitivity: 3 people, 27.27%
Rickets (softening of bones): 2 people, 18.18%
Restless Leg Syndrome (a powerful urge to move your legs): 2 people, 18.18%
Pollakiuria (abnormally frequent passage of relatively small quantities or urine): 2 people, 18.18%
Pain In Extremity: 2 people, 18.18%
Muscle Spasms (muscle contraction): 2 people, 18.18%
Muscle Aches (muscle pain): 2 people, 18.18%
Joint Pain: 2 people, 18.18%
High Blood Pressure: 2 people, 18.18%

* Approximation only. Some reports may have incomplete information.

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