Zonisamide and Otezla drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zonisamide (zonisamide) and Otezla (apremilast). Common drug interactions include back pain among females and alanine aminotransferase increased among males.

The phase IV clinical study analyzes what interactions people have when they take Zonisamide and Otezla. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Zonisamide?

Zonisamide has active ingredients of zonisamide. It is often used in epilepsy. eHealthMe is studying from 11,445 Zonisamide users. Check the latest studies of Zonisamide.

What is Otezla?

Otezla has active ingredients of apremilast. It is often used in psoriatic arthritis. eHealthMe is studying from 146,254 Otezla users. Check the latest studies of Otezla.

On Jul, 28, 2026

19 people who take Zonisamide and Otezla together, and have interactions are studied.

Zonisamide and Otezla drug interactions.

What are the common drug interactions of Zonisamide and Otezla, by gender? *:

female:

Back pain
Discomfort
Psoriasis (immune-mediated disease that affects the skin)
Tenderness (pain or discomfort when an affected area is touched)
Nausea (feeling of having an urge to vomit)
Peripheral swelling
Pulmonary mass
Rash generalised (rash on most of body parts)
Respiratory tract infection
Skin irritation

male:

Alanine aminotransferase increased
Aspartate aminotransferase increased
Blood alkaline phosphatase increased
Diarrhoea
Gamma-glutamyltransferase increased
Hepatic enzyme increased
Psoriasis (immune-mediated disease that affects the skin)
Myasthenia gravis (a chronic condition that causes muscles to tire and weaken easily)

What are the common drug interactions of Zonisamide and Otezla, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Arthralgia (joint pain)
Diarrhoea
Fatigue (feeling of tiredness)
Headache (pain in head)
Psoriasis (immune-mediated disease that affects the skin)

40-49:

Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Pain
Peripheral swelling
Pulmonary mass
Respiratory tract infection

50-59:

Alopecia (absence of hair from areas of the body)
Chills (felling of cold)
Diarrhoea
Hyperhidrosis (abnormally increased sweating)
Infection
Myasthenia gravis (a chronic condition that causes muscles to tire and weaken easily)
Nausea (feeling of having an urge to vomit)
Psoriasis (immune-mediated disease that affects the skin)
Sinus congestion (blockage of sinus)

60+:

Diarrhoea
Headache (pain in head)
Vomiting
Back pain
Discomfort
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Psoriasis (immune-mediated disease that affects the skin)
Tenderness (pain or discomfort when an affected area is touched)
Eructation (release of gas from the digestive tract)
Nausea (feeling of having an urge to vomit)

What are the existing conditions these people have? *

Psoriasis (immune-mediated disease that affects the skin): 15 people, 78.95%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 3 people, 15.79%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 3 people, 15.79%
Gastric Ulcer (stomach ulcer): 3 people, 15.79%
Hepatic Cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue): 3 people, 15.79%
High Blood Pressure: 3 people, 15.79%
Iron Deficiency: 3 people, 15.79%
Pain: 3 people, 15.79%
Joint Pain: 2 people, 10.53%
Polyneuropathy (neurological disorder that occurs when many peripheral nerves throughout the body malfunction simultaneously): 2 people, 10.53%

* Approximation only. Some reports may have incomplete information.

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