Zonisamide and Pepcid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zonisamide (zonisamide) and Pepcid (famotidine). Common drug interactions include palpitations among females and pyrexia among males.

The phase IV clinical study analyzes what interactions people have when they take Zonisamide and Pepcid. It is created by eHealthMe based on reports of 69 people who take the same drugs from the FDA, and is updated regularly.

What is Zonisamide?

Zonisamide has active ingredients of zonisamide. It is often used in epilepsy. eHealthMe is studying from 11,445 Zonisamide users. Check the latest studies of Zonisamide.

What is Pepcid?

Pepcid has active ingredients of famotidine. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 55,774 Pepcid users. Check the latest studies of Pepcid.

On Aug, 05, 2026

69 people who take Zonisamide and Pepcid together, and have interactions are studied.

Zonisamide and Pepcid drug interactions.

What are the common drug interactions of Zonisamide and Pepcid, by gender? *:

female:

Palpitations (feelings or sensations that your heart is pounding or racing)
Renal injury (kidney injury)
Headache (pain in head)
Hypophosphataemia (electrolyte disturbance in which there is an abnormally low level of phosphate in the blood)
Malaise (a feeling of general discomfort or uneasiness)
Presyncope
Renal failure (kidney dysfunction)
Anxiety
Arthralgia (joint pain)
Dizziness

male:

Pyrexia (fever)
Drug rash with eosinophilia and systemic symptoms (adverse drug reactions with rash)
Chronic kidney disease
Constipation
Dehydration (dryness resulting from the removal of water)
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Fall
Hypotension (abnormally low blood pressure)
Lung infiltration (a substance that normally includes fluid, inflammatory exudates or cells that fill a region of lung)
Oedema (fluid collection in tissue)

What are the common drug interactions of Zonisamide and Pepcid, by age (0-1 to 60+)? *:

0-1:

Constipation
Eye movement disorder
Haematochezia (passage of stools containing blood)
Hemiparesis (weakness on one side of the body)
Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)
Muscle spasms (muscle contraction)
Seizure cluster (small group of seizure)

2-9:

Injection site pain
Injection site warmth
Lymphadenopathy (disease or enlargement of lymph nodes)
Oesophageal irritation
Oesophagitis (inflammation of oesophagus)
Rectal haemorrhage (bleeding from anus)
Abdominal pain
Acidosis (build-up of carbon dioxide in the blood)
Drug ineffective
Status epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure)

10-19:

Hypersomnia (excessive daytime sleepiness (eds))
Electrocardiogram qt prolonged
Nausea (feeling of having an urge to vomit)
Abdominal discomfort
Diarrhoea
Adverse drug reaction
Hypophagia (reduced food intake)
Abdominal distension
Abdominal pain
Abscess jaw (tooth abscess or root abscess)

20-29:

n/a

30-39:

Chronic kidney disease
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Fall
Renal failure (kidney dysfunction)
Subarachnoid haemorrhage (blood leaks into the space between two membranes that surround the brain)
Traumatic intracranial haemorrhage (a bleeding in brain due to trauma)

40-49:

Chronic kidney disease
Ankle fracture
Headache (pain in head)
Hypertension (high blood pressure)
Impaired gastric emptying
Infusion related reaction
Meningitis aseptic (a condition that causes the membranes covering your brain and spinal cord to become inflamed)
Pyrexia (fever)
Renal failure (kidney dysfunction)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)

50-59:

Anuria (failure of the kidneys to produce urine)
Blood creatinine increased
Blood urea increased
Cardiac arrest
Chronic kidney disease
Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Encephalopathy (functioning of the brain is affected by some agent or condition)

60+:

Chronic kidney disease
Drug rash with eosinophilia and systemic symptoms (adverse drug reactions with rash)
Viraemia (presence of a virus in the blood stream)
Vomiting
Cardiac arrest
Electrocardiogram abnormal
Full blood count decreased
Haematocrit decreased
Haemodynamic instability (disturbances in the blood movement in our body)
Haemoglobin decreased

What are the existing conditions these people have? *

Pain: 11 people, 15.94%
Headache (pain in head): 9 people, 13.04%
Constipation: 9 people, 13.04%
Cough: 9 people, 13.04%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 8 people, 11.59%
Asthma: 8 people, 11.59%
Allergic Rhinitis: 7 people, 10.14%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 7 people, 10.14%
Fever: 6 people, 8.70%
Stress And Anxiety: 6 people, 8.70%

* Approximation only. Some reports may have incomplete information.

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