Zonisamide and Temazepam drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zonisamide (zonisamide) and Temazepam (temazepam). Common drug interactions include urinary retention among females and arthritis among males.

The phase IV clinical study analyzes what interactions people have when they take Zonisamide and Temazepam. It is created by eHealthMe based on reports of 46 people who take the same drugs from the FDA, and is updated regularly.

What is Zonisamide?

Zonisamide has active ingredients of zonisamide. It is often used in epilepsy. eHealthMe is studying from 11,445 Zonisamide users. Check the latest studies of Zonisamide.

What is Temazepam?

Temazepam has active ingredients of temazepam. It is often used in insomnia. eHealthMe is studying from 42,106 Temazepam users. Check the latest studies of Temazepam.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

46 people who take Zonisamide and Temazepam together, and have interactions are studied.

Zonisamide and Temazepam drug interactions.

What are the common drug interactions of Zonisamide and Temazepam, by gender? *:

female:

Urinary retention (the inability to completely or partially empty the bladder)
Drug administration error
Chronic kidney disease
Chest pain
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Lymphocyte count decreased
Neck pain
Nephrogenic anaemia (anaemia due to kidney disease)
Adenomyosis (presence of ectopic glandular tissue found in muscle)

male:

Arthritis (form of joint disorder that involves inflammation of one or more joints)
Asthenia (weakness)
Acidosis (build-up of carbon dioxide in the blood)
Schizophrenia (a mental disorder characterized by a breakdown of thought processes)
Abdominal discomfort
Abnormal dreams
Blood pressure increased
Bradycardia (abnormally slow heart action)
Completed suicide (act of taking one's own life)
Confusional state

What are the common drug interactions of Zonisamide and Temazepam, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Adenomyosis (presence of ectopic glandular tissue found in muscle)
Dyspareunia (painful sexual intercourse)
Glaucoma (increased fluid pressure in the eye with vision loss)
Pelvic pain
Rectocele (a bulging of the front wall of the rectum into the back wall of the vagina)
Stress urinary incontinence (leak urine with things like coughing, sneezing or exercise)
Urethral disorder
Weight increased
Acidosis (build-up of carbon dioxide in the blood)
Schizophrenia (a mental disorder characterized by a breakdown of thought processes)

40-49:

Neck pain
Asthenia (weakness)
Pneumonia
Sudden onset of sleep
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Back pain
Bipolar disorder (mood disorder)
Chills (felling of cold)
Depression
Drug ineffective

50-59:

Urinary retention (the inability to completely or partially empty the bladder)
Drug administration error
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Asthenia (weakness)
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Haemorrhage (bleeding)
Pain
Pneumonia
Chest pain
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)

60+:

Chronic kidney disease
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Headache (pain in head)
Renal failure (kidney dysfunction)
Renal impairment (severely reduced kidney function)
Road traffic accident
Syncope (loss of consciousness with an inability to maintain postural tone)
Nephrogenic anaemia (anaemia due to kidney disease)
Abdominal discomfort
Confusional state

What are the existing conditions these people have? *

Stress And Anxiety: 5 people, 10.87%
High Blood Pressure: 5 people, 10.87%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 10.87%
Depression: 5 people, 10.87%
Sleep Disorder: 4 people, 8.70%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 8.70%
Pain: 4 people, 8.70%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 8.70%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 8.70%
High Blood Cholesterol: 4 people, 8.70%

* Approximation only. Some reports may have incomplete information.

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