Zonisamide and Tolterodine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zonisamide (zonisamide) and Tolterodine (tolterodine tartrate). Common drug interactions include sinusitis among females and bronchitis among males.

The phase IV clinical study analyzes what interactions people have when they take Zonisamide and Tolterodine. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Zonisamide?

Zonisamide has active ingredients of zonisamide. It is often used in epilepsy. eHealthMe is studying from 11,445 Zonisamide users. Check the latest studies of Zonisamide.

What is Tolterodine?

Tolterodine has active ingredients of tolterodine tartrate. It is often used in urge incontinence. eHealthMe is studying from 8,156 Tolterodine users. Check the latest studies of Tolterodine.



On Jul, 31, 2026

14 people who take Zonisamide and Tolterodine together, and have interactions are studied.

Zonisamide and Tolterodine drug interactions.

What are the common drug interactions of Zonisamide and Tolterodine, by gender? *:

female:

  1. Sinusitis (inflammation of sinus)
  2. Suicidal ideation
  3. Fibromyalgia (a long-term condition which causes pain all over the body)
  4. Back pain
  5. Blood pressure increased
  6. Cough
  7. Drug ineffective
  8. Hypertension (high blood pressure)
  9. Rhinorrhoea (watery mucus discharge from the nose)
  10. Nausea (feeling of having an urge to vomit)

male:

  1. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
  2. Quality of life decreased

What are the common drug interactions of Zonisamide and Tolterodine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Anxiety
  2. Nausea (feeling of having an urge to vomit)
  3. Visual impairment

30-39:

n/a

40-49:

  1. Headache (pain in head)
  2. Oropharyngeal pain
  3. Throat irritation
  4. Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
  5. Drug ineffective

50-59:

n/a

60+:

  1. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
  2. Quality of life decreased

What are the existing conditions these people have? *

  1. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 8 people, 57.14%
  2. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 28.57%
  3. Sleep Disorder: 3 people, 21.43%
  4. Oral Herpes (viral infection of mouth): 3 people, 21.43%
  5. Muscle Spasms (muscle contraction): 3 people, 21.43%
  6. Headache (pain in head): 3 people, 21.43%
  7. Migraine (headache): 2 people, 14.29%
  8. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 14.29%
  9. High Blood Cholesterol: 1 person, 7.14%
  10. Bladder Disorder: 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Zonisamide and Tolterodine?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Zonisamide and Tolterodine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Zonisamide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Tolterodine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Zonisamide and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Tolterodine and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on zonisamide and tolterodine tartrate (the active ingredients of Zonisamide and Tolterodine, respectively), and Zonisamide and Tolterodine (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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