Zonisamide and Yaz drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zonisamide (zonisamide) and Yaz (drospirenone; ethinyl estradiol). Common drug interactions include pain among females and pain among males.

The phase IV clinical study analyzes what interactions people have when they take Zonisamide and Yaz. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Zonisamide?

Zonisamide has active ingredients of zonisamide. It is often used in epilepsy. eHealthMe is studying from 11,445 Zonisamide users. Check the latest studies of Zonisamide.

What is Yaz?

Yaz has active ingredients of drospirenone; ethinyl estradiol. It is often used in birth control. eHealthMe is studying from 41,514 Yaz users. Check the latest studies of Yaz.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 25, 2026

16 people who take Zonisamide and Yaz together, and have interactions are studied.

What are the common drug interactions of Zonisamide and Yaz, by gender? *:

female:

Pain
Anxiety
Diarrhoea
Injury
Nausea (feeling of having an urge to vomit)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Cholecystitis chronic (long lasting infection of gallbladder)
Abdominal distension
Constipation

male:

Pain
Anxiety
Haemorrhage (bleeding)
Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Gallbladder disorder
Injection site pain
Injury
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Abdominal pain
Cholecystitis chronic (long lasting infection of gallbladder)

What are the common drug interactions of Zonisamide and Yaz, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Thrombosis (formation of a blood clot inside a blood vessel)

20-29:

Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Cholecystitis chronic (long lasting infection of gallbladder)
Diarrhoea
Nausea (feeling of having an urge to vomit)
Abdominal discomfort
Abdominal pain
Abdominal pain upper
Cholesterosis (abnormal deposition of cholesterol in tissues)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Faeces discoloured

30-39:

Pain
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Pulmonary embolism (blockage of the main artery of the lung)
Injury
Chest pain
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dyspnoea (difficult or laboured respiration)
Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Gallbladder disorder
Injection site pain

40-49:

Anxiety
Cholecystitis (infection of gallbladder)
Injury
Pain
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Intracranial venous sinus thrombosis (presence of thrombosis (a blood clot) in the dural venous sinuses, which drain blood from the brain)

50-59:

Abdominal distension
Anxiety
Constipation
Depression
Diarrhoea
Dyspepsia (indigestion)
Flatulence (flatus expelled through the anus)
Scar
Nausea (feeling of having an urge to vomit)

60+:

Anxiety
Emotional distress
Haemorrhage (bleeding)
Abdominal pain
Cholecystitis chronic (long lasting infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Drug rash with eosinophilia and systemic symptoms (adverse drug reactions with rash)
Nausea (feeling of having an urge to vomit)
Pancreatic injury
Vomiting

What are the existing conditions these people have? *

Migraine (headache): 6 people, 37.50%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 31.25%
Premenstrual Syndrome: 4 people, 25.00%
Pain: 4 people, 25.00%
Asthma: 3 people, 18.75%
Stress And Anxiety: 3 people, 18.75%
Constipation: 3 people, 18.75%
Joint Pain: 2 people, 12.50%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 2 people, 12.50%
Back Pain: 2 people, 12.50%

* Approximation only. Some reports may have incomplete information.

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