Zonisamide and Zyprexa drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zonisamide (zonisamide) and Zyprexa (olanzapine). Common drug interactions include ear infection among females and aggression among males.

The phase IV clinical study analyzes what interactions people have when they take Zonisamide and Zyprexa. It is created by eHealthMe based on reports of 43 people who take the same drugs from the FDA, and is updated regularly.

What is Zonisamide?

Zonisamide has active ingredients of zonisamide. It is often used in epilepsy. eHealthMe is studying from 11,445 Zonisamide users. Check the latest studies of Zonisamide.

What is Zyprexa?

Zyprexa has active ingredients of olanzapine. It is often used in bipolar disorder. eHealthMe is studying from 64,724 Zyprexa users. Check the latest studies of Zyprexa.

On Jul, 27, 2026

43 people who take Zonisamide and Zyprexa together, and have interactions are studied.

Zonisamide and Zyprexa drug interactions.

What are the common drug interactions of Zonisamide and Zyprexa, by gender? *:

female:

Ear infection
Non-hodgkin's lymphoma (malignant (cancer) cells form in the lymph system)
Urinary tract infection
Dry eye (lack of adequate tears)
Autonomic neuropathy (malfunction of the autonomic nervous system (ans))
Infection
Migraine with aura (headache with vision weakness)
Type 2 diabetes mellitus
Haemorrhage (bleeding)
Dementia (madness)

male:

Aggression
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Dysphagia (a condition in which swallowing is difficult or painful)
Abnormal behaviour
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetic coma
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Dysarthria (speech disorder)
Dyspepsia (indigestion)
Hyperammonaemia

What are the common drug interactions of Zonisamide and Zyprexa, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Aggression
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetic coma
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Dyspepsia (indigestion)
Hyperglycaemia (high blood sugar)
Insomnia (sleeplessness)
Pancreatitis (inflammation of pancreas)
Weight increased

30-39:

Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Surgery
Visual acuity reduced (reduced clearness of vision)

40-49:

Abnormal behaviour
Aggression
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Dysarthria (speech disorder)
Hyperammonaemia
Postictal state
Psychotic disorder
Chronic kidney disease
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

50-59:

Aortic aneurysm (enlargement of an aortic artery caused by a weakening of the artery wall)
Haematuria (presence of blood in urine)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Autonomic neuropathy (malfunction of the autonomic nervous system (ans))
Cardiomegaly (increased size of heart than normal)
Dementia (madness)
Dry eye (lack of adequate tears)
Haemorrhage (bleeding)
Infection
Migraine with aura (headache with vision weakness)

60+:

Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Frostbite (damage is caused to skin and other tissues due to freezing)
Sepsis (a severe blood infection that can lead to organ failure and death)
Abdominal pain
Blood bilirubin increased
Blood pressure increased
Diarrhoea
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Gingival pain (gum pain)
Hypokalaemia (low potassium)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 24 people, 55.81%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 24 people, 55.81%
High Blood Pressure: 5 people, 11.63%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 4 people, 9.30%
Cerebral Infarction (less blood supply to brain resulting tissue damage): 4 people, 9.30%
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure): 4 people, 9.30%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 4 people, 9.30%
Agitation (state of anxiety or nervous excitement): 4 people, 9.30%

* Approximation only. Some reports may have incomplete information.

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