Zopiclone and Adcirca drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zopiclone (eszopiclone) and Adcirca (tadalafil). Common drug interactions include anxiety among females and bronchitis among males.

The phase IV clinical study analyzes what interactions people have when they take Zopiclone and Adcirca. It is created by eHealthMe based on reports of 62 people who take the same drugs from the FDA, and is updated regularly.

What is Zopiclone?

Zopiclone has active ingredients of eszopiclone. It is often used in insomnia. eHealthMe is studying from 54,330 Zopiclone users. Check the latest studies of Zopiclone.

What is Adcirca?

Adcirca has active ingredients of tadalafil. It is often used in pulmonary hypertension. eHealthMe is studying from 54,957 Adcirca users. Check the latest studies of Adcirca.



On Jul, 13, 2026

62 people who take Zopiclone and Adcirca together, and have interactions are studied.

Zopiclone and Adcirca drug interactions.

What are the common drug interactions of Zopiclone and Adcirca, by gender? *:

female:

  1. Anxiety
  2. Asthenia (weakness)
  3. Back pain
  4. Cough
  5. Death
  6. Decreased appetite
  7. Drug ineffective
  8. Fear
  9. Hot flush (sudden feelings of heat)
  10. Panic attack

male:

  1. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
  2. Nausea (feeling of having an urge to vomit)
  3. Platelet count decreased
  4. Sensory loss (senses loss)
  5. Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin)
  6. Chest pain
  7. Injection site bruising
  8. Pain
  9. Anaemia (lack of blood)
  10. Decreased appetite

What are the common drug interactions of Zopiclone and Adcirca, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Hospitalisation
  2. Nonspecific reaction (unspecified reaction)

40-49:

  1. Headache (pain in head)
  2. Hallucination (an experience involving the perception of something not present)
  3. Oedema peripheral (superficial swelling)

50-59:

  1. Arthralgia (joint pain)
  2. Blood pressure increased
  3. Body temperature increased
  4. Diarrhoea
  5. Drug ineffective
  6. Fatigue (feeling of tiredness)
  7. Fibromyalgia (a long-term condition which causes pain all over the body)
  8. Food poisoning (poison in food)
  9. Heart rate increased
  10. Immune system disorder

60+:

  1. Headache (pain in head)
  2. Diarrhoea
  3. Decreased appetite
  4. Dizziness
  5. Hyperhidrosis (abnormally increased sweating)
  6. Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
  7. Asthenia (weakness)
  8. Back pain
  9. Cough
  10. Hospitalisation

What are the existing conditions these people have? *

  1. Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 46 people, 74.19%
  2. Right Ventricular Failure (right half of the heart fails to work): 5 people, 8.06%
  3. Pneumonia: 5 people, 8.06%
  4. Neuropathy Peripheral (surface nerve damage): 5 people, 8.06%
  5. Generalized Anxiety Disorder (excessive, uncontrollable, unexplained and often irrational worry): 5 people, 8.06%
  6. Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 5 people, 8.06%
  7. Back Pain: 5 people, 8.06%
  8. Raynaud's Phenomenon (discoloration of the fingers, toes, and occasionally other areas): 4 people, 6.45%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Zopiclone and Adcirca:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Zopiclone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Adcirca:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Zopiclone and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Adcirca and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on eszopiclone and tadalafil (the active ingredients of Zopiclone and Adcirca, respectively), and Zopiclone and Adcirca (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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