Zosyn and Aminocaproic drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zosyn (piperacillin sodium; tazobactam sodium) and Aminocaproic (aminocaproic acid). Common drug interactions include chronic kidney disease among females and sepsis among males.

The phase IV clinical study analyzes what interactions people have when they take Zosyn and Aminocaproic. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Zosyn?

Zosyn has active ingredients of piperacillin sodium; tazobactam sodium. It is often used in pneumonia. eHealthMe is studying from 10,236 Zosyn users. Check the latest studies of Zosyn.

What is Aminocaproic?

Aminocaproic has active ingredients of aminocaproic acid. eHealthMe is studying from 737 Aminocaproic users. Check the latest studies of Aminocaproic.



On Jul, 16, 2026

17 people who take Zosyn and Aminocaproic together, and have interactions are studied.

Zosyn and Aminocaproic drug interactions.

What are the common drug interactions of Zosyn and Aminocaproic, by gender? *:

female:

  1. Chronic kidney disease
  2. Nephrogenic anaemia (anaemia due to kidney disease)
  3. Renal failure (kidney dysfunction)
  4. Sepsis (a severe blood infection that can lead to organ failure and death)
  5. Abscess limb (limb infection)
  6. Anal abscess
  7. Cardiac arrest
  8. Cardiomyopathy (weakening of the heart muscle)
  9. Cellulitis (infection under the skin)
  10. Genital abscess (build up of pus in genital)

male:

  1. Sepsis (a severe blood infection that can lead to organ failure and death)
  2. Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
  3. Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
  4. Dysstasia (difficulty in standing)
  5. Emotional distress
  6. Fascial infection (infection in muscle surrounding tissue)
  7. Folliculitis (infection of hair root)
  8. Gait disturbance
  9. Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
  10. General physical health deterioration (weak health status)

What are the common drug interactions of Zosyn and Aminocaproic, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Aortic valve disease
  2. Cardiac failure congestive
  3. Cardiac valve disease (heart valve disease)
  4. Cerebral artery embolism (sudden blocking of an artery by a clot or foreign material)
  5. Cerebral infarction (less blood supply to brain resulting tissue damage)
  6. Coma (state of unconsciousness lasting more than six hours)
  7. Kidney transplant rejection
  8. Leukaemoid reaction (elevated white blood cell count, or leukocytosis, that is a physiological response to stress or infection)
  9. Post procedural complication
  10. Pseudobulbar palsy (inability to control facial movements (such as chewing and speaking))

40-49:

  1. Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
  2. Perineal abscess
  3. Sepsis (a severe blood infection that can lead to organ failure and death)
  4. Anal abscess
  5. Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
  6. Fascial infection (infection in muscle surrounding tissue)
  7. Folliculitis (infection of hair root)
  8. Groin abscess (pus in groin)
  9. Hyperglycaemia (high blood sugar)
  10. Hypertension (high blood pressure)

50-59:

  1. Renal failure (kidney dysfunction)
  2. Sepsis (a severe blood infection that can lead to organ failure and death)
  3. Abscess limb (limb infection)
  4. Anal abscess
  5. Cardiac arrest
  6. Cardiomyopathy (weakening of the heart muscle)
  7. Cellulitis (infection under the skin)
  8. Genital abscess (build up of pus in genital)
  9. Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
  10. Hypertension (high blood pressure)

60+:

  1. Bacteraemia (presence of bacteria in the blood)
  2. Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
  3. Pulmonary embolism (blockage of the main artery of the lung)
  4. Gastric haemorrhage (bleeding stomach)
  5. Multi-organ failure (multisystem organ failure)
  6. Peripheral t-cell lymphoma unspecified (peripheral t-cell cancer unspecified)
  7. Sepsis syndrome (a clinical condition of blood infection)
  8. Sinusitis fungal (fungal infection of sinus)

What are the existing conditions these people have? *

  1. Diabetes: 5 people, 29.41%
  2. High Blood Pressure: 4 people, 23.53%
  3. Hypersensitivity: 4 people, 23.53%
  4. Blood Pressure Abnormal: 3 people, 17.65%
  5. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 17.65%
  6. Pain: 3 people, 17.65%
  7. Type 2 Diabetes: 3 people, 17.65%
  8. Weight Decreased: 2 people, 11.76%
  9. Multiple Myeloma (cancer of the plasma cells): 2 people, 11.76%
  10. Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 2 people, 11.76%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Zosyn and Aminocaproic:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Zosyn:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Aminocaproic:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Zosyn and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Aminocaproic and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on piperacillin sodium; tazobactam sodium and aminocaproic acid (the active ingredients of Zosyn and Aminocaproic, respectively), and Zosyn and Aminocaproic (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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