Zosyn and Ceftriaxone sodium drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zosyn (piperacillin sodium; tazobactam sodium) and Ceftriaxone sodium (ceftriaxone sodium). Common drug interactions include oedema peripheral among females and pyrexia among males.

The phase IV clinical study analyzes what interactions people have when they take Zosyn and Ceftriaxone sodium. It is created by eHealthMe based on reports of 94 people who take the same drugs from the FDA, and is updated regularly.

What is Zosyn?

Zosyn has active ingredients of piperacillin sodium; tazobactam sodium. It is often used in pneumonia. eHealthMe is studying from 10,236 Zosyn users. Check the latest studies of Zosyn.

What is Ceftriaxone sodium?

Ceftriaxone sodium has active ingredients of ceftriaxone sodium. eHealthMe is studying from 6,549 Ceftriaxone sodium users. Check the latest studies of Ceftriaxone sodium.

On Jul, 25, 2026

94 people who take Zosyn and Ceftriaxone sodium together, and have interactions are studied.

Zosyn and Ceftriaxone sodium drug interactions.

What are the common drug interactions of Zosyn and Ceftriaxone Sodium, by gender? *:

female:

Oedema peripheral (superficial swelling)
Oesophageal rupture (break in oesophagus)
Pleural effusion (water on the lungs)
Relapsing fever (bacterial infection characterized by recurring episodes of fever, headache, muscle and joint aches, and nausea)
Spinal compression fracture (fracture due to spinal compression on bone)
Vomiting
Hypokalaemia (low potassium)
Rash generalised (rash on most of body parts)
Hypotension (abnormally low blood pressure)
Immunodeficiency

male:

Pyrexia (fever)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Retinal vein occlusion (a blockage of the small veins that carry blood away from the retina)
Stomatitis (inflammation of mucous membrane of mouth)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Adverse reaction
Biliary neoplasm (biliary tumour)
Bronchitis bacterial (inflammation of the mucous membrane in the bronchial tubes due to bacterial infection)
Gastric ulcer (stomach ulcer)
Lung neoplasm malignant (cancer tumour of lung)

What are the common drug interactions of Zosyn and Ceftriaxone Sodium, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Arthralgia (joint pain)
Brain abscess
Eye injury
Eye swelling
Hepatic enzyme increased
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Subdural empyema (collection of supportive material between the dura mater and arachnoids surrounding the brain)

20-29:

Hypotension (abnormally low blood pressure)
Immunodeficiency
Phlebitis (inflammation of the walls of a vein)
Pulmonary vascular disorder
Respiratory distress (difficulty in breathing)
Vasculitis (inflammation of a blood vessel or blood vessels)
Respiratory depression (respiration has a rate below 12 breaths)
Abdominal pain
Anxiety
Blood pressure decreased

30-39:

Cystitis (inflammation of the wall of the bladder)
Escherichia infection (bacterial infection by escherichia coli)
Lupus nephritis (a chronic inflammatory autoimmune disorder that may affect kidney tissue)
Nephrolithiasis (calculi in the kidneys)
Pyelonephritis acute (sudden inflammation of kidney caused by bacteria)
Pregnancy with contraceptive device

40-49:

Sepsis (a severe blood infection that can lead to organ failure and death)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Alopecia (absence of hair from areas of the body)
Decreased appetite
Diarrhoea
Febrile neutropenia (fever with reduced white blood cells)
Haematuria (presence of blood in urine)
Hiccups (an involuntary spasm of the diaphragm and respiratory organs, with a sudden closure of the glottis and a sound like a cough)
Lower gastrointestinal haemorrhage (bleeding in the large intestine, rectum, or anus is called lower gi bleeding)
Malaise (a feeling of general discomfort or uneasiness)

50-59:

Blood creatine phosphokinase increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Bronchopulmonary aspergillosis (lung disorder caused by aspergillus fungi)
Cerumen impaction
Chronic graft versus host disease (immune cells attack the host's body cells after transplant)
Constipation
Dermal cyst
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diarrhoea
Duodenal ulcer

60+:

Febrile neutropenia (fever with reduced white blood cells)
Diarrhoea
Hypocalcaemia (levels of calcium in blood serum are abnormally low)
Injection site erythema (redness at injection site)
Oedema peripheral (superficial swelling)
Oesophageal rupture (break in oesophagus)
Relapsing fever (bacterial infection characterized by recurring episodes of fever, headache, muscle and joint aches, and nausea)
Spinal compression fracture (fracture due to spinal compression on bone)
Vomiting
Pyrexia (fever)

What are the existing conditions these people have? *

Pneumonia: 32 people, 34.04%
Fever: 22 people, 23.40%
High Blood Pressure: 21 people, 22.34%
Myelodysplastic Syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged): 19 people, 20.21%
Constipation: 17 people, 18.09%
Sepsis (a severe blood infection that can lead to organ failure and death): 15 people, 15.96%
Nausea (feeling of having an urge to vomit): 14 people, 14.89%
Insomnia (sleeplessness): 13 people, 13.83%
Rashes (redness): 12 people, 12.77%
Back Pain: 12 people, 12.77%

* Approximation only. Some reports may have incomplete information.

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