Zosyn and Macrobid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zosyn (piperacillin sodium; tazobactam sodium) and Macrobid (nitrofurantoin; nitrofurantoin, macrocrystalline). Common drug interactions include sensation of pressure among females and dyspnoea among males.

The phase IV clinical study analyzes what interactions people have when they take Zosyn and Macrobid. It is created by eHealthMe based on reports of 43 people who take the same drugs from the FDA, and is updated regularly.

What is Zosyn?

Zosyn has active ingredients of piperacillin sodium; tazobactam sodium. It is often used in pneumonia. eHealthMe is studying from 10,236 Zosyn users. Check the latest studies of Zosyn.

What is Macrobid?

Macrobid has active ingredients of nitrofurantoin; nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. eHealthMe is studying from 9,215 Macrobid users. Check the latest studies of Macrobid.

On Jul, 18, 2026

43 people who take Zosyn and Macrobid together, and have interactions are studied.

What are the common drug interactions of Zosyn and Macrobid, by gender? *:

female:

Sensation of pressure
Swelling face
Traumatic haematoma (a blood clot in body due to trauma)
Vomiting
Anaemia (lack of blood)
Anastomotic leak
Anxiety
Contusion (a type of hematoma of tissue in which capillaries)
Faecaloma (hard mass of fecal matter)
Ureteric obstruction

male:

Dyspnoea (difficult or laboured respiration)
Aortic arteriosclerosis (hardening of the aortic arteries)
Gait disturbance
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hyperhidrosis (abnormally increased sweating)
Hypertension (high blood pressure)
Hypokalaemia (low potassium)
Hypotension (abnormally low blood pressure)
Injury
Memory impairment

What are the common drug interactions of Zosyn and Macrobid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Nephrolithiasis (calculi in the kidneys)

20-29:

n/a

30-39:

Anal abscess
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Arterial thrombosis limb (formation of a blood clot inside a blood vessel, obstructing the flow of blood through the circulatory system-limb)
Cellulitis (infection under the skin)
Cholecystitis (infection of gallbladder)
Emotional distress
Gallbladder injury
General physical health deterioration (weak health status)
Genital abscess (build up of pus in genital)

40-49:

Arthralgia (joint pain)
Benign neoplasm of thyroid gland (benign (non-cancerous) tumours of the thyroid gland)
Bone disorder
Colon neoplasm (cancer from uncontrolled cell growth in the colon or rectum)
Decreased interest
Defaecation urgency (a sudden compelling urge to defecate)
Depression
Dysfunctional uterine bleeding
Dyspnoea (difficult or laboured respiration)
Emotional distress

50-59:

Aspartate aminotransferase increased
Diarrhoea
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Nausea (feeling of having an urge to vomit)
Thrombocytopenia (decrease of platelets in blood)
Vomiting
Chronic kidney disease
Renal failure (kidney dysfunction)
Renal tubular necrosis (death of kidney tubules)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)

60+:

Nausea (feeling of having an urge to vomit)
Malaise (a feeling of general discomfort or uneasiness)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Headache (pain in head)
Hypertension (high blood pressure)
Pneumonia pseudomonal (pseudomonas pneumonia is an infection caused by the microbe known as pseudomonas aeruginosa)
Respiratory tract infection bacterial
Asthenia (weakness)
Back pain
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 10 people, 23.26%
Diarrhea: 9 people, 20.93%
Metastases To Bone (cancer spreads to bone): 7 people, 16.28%
High Blood Pressure: 7 people, 16.28%
Short-Bowel Syndrome (a condition in which the body cannot absorb enough fluids and nutrients because part of the small intestine is missing): 6 people, 13.95%
Hiv Infection: 6 people, 13.95%
Depression: 6 people, 13.95%
Asthma: 6 people, 13.95%
Respiratory Tract Infection Viral: 5 people, 11.63%
Respiratory Tract Infection Bacterial: 5 people, 11.63%

* Approximation only. Some reports may have incomplete information.

Do you take Zosyn and Macrobid?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously