Zosyn and Peridex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zosyn (piperacillin sodium; tazobactam sodium) and Peridex (chlorhexidine gluconate). Common drug interactions include atelectasis among females and back pain among males.

The phase IV clinical study analyzes what interactions people have when they take Zosyn and Peridex. It is created by eHealthMe based on reports of 93 people who take the same drugs from the FDA, and is updated regularly.

What is Zosyn?

Zosyn has active ingredients of piperacillin sodium; tazobactam sodium. It is often used in pneumonia. eHealthMe is studying from 10,236 Zosyn users. Check the latest studies of Zosyn.

What is Peridex?

Peridex has active ingredients of chlorhexidine gluconate. eHealthMe is studying from 2,803 Peridex users. Check the latest studies of Peridex.

On Jul, 16, 2026

93 people who take Zosyn and Peridex together, and have interactions are studied.

What are the common drug interactions of Zosyn and Peridex, by gender? *:

female:

Atelectasis (partial or complete collapse of the lung)
Osteonecrosis of jaw (death of bone of jaw)
Syncope (loss of consciousness with an inability to maintain postural tone)
Thrombocytopenia (decrease of platelets in blood)
Anxiety
Back pain
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dyspnoea (difficult or laboured respiration)
Loss of consciousness

male:

Back pain
Pain in extremity
Mouth ulceration (mouth ulcers)
Nephrolithiasis (calculi in the kidneys)
Oral herpes (viral infection of mouth)
Sinus disorder (disease of sinus)
Tooth infection
Lichen planus (an inflammatory skin condition, characterized by an itchy, non-infectious rash)
Thrombocytopenia (decrease of platelets in blood)
Tooth fracture

What are the common drug interactions of Zosyn and Peridex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Anaemia (lack of blood)
Back pain
Delayed engraftment
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Haemolysis (breaking open of red blood cells and the release of haemoglobin into the surrounding fluid)
Headache (pain in head)
Hyperbilirubinaemia (excess of bilirubin in the blood)
Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection)
Hypotension (abnormally low blood pressure)
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)

10-19:

Bradycardia (abnormally slow heart action)
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Hypoxia (low oxygen in tissues)
Neurotoxicity (when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system)
Acute lymphocytic leukaemia recurrent (cancer in which the bone marrow makes too many lymphocytes-recurrent)
Appetite disorder (abnormal eating habits)
Blood creatinine increased
Blood lactic acid increased
Blood urea increased
Bone marrow failure

20-29:

Alopecia (absence of hair from areas of the body)
Anaemia (lack of blood)
Arthralgia (joint pain)
Brain compression
Breast cancer stage iii
Breast fibrosis (the thickening and scarring of connective tissue, usually as a result of injury in breast)
Breast inflammation
Cerebellar infarction (impaired blood circulation to cerebellum)
Dental caries
Dermoid cyst (an abnormal growth (teratoma) containing epidermis, hair follicles, and sebaceous glands)

30-39:

Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Contrast media reaction (reaction associated with the use of intravenous contrast material during radiology)
Headache (pain in head)

40-49:

Diarrhoea
Anxiety
Back pain
Bone disorder
Bone pain
Cellulitis (infection under the skin)
Injury
Mouth ulceration (mouth ulcers)
Nephrolithiasis (calculi in the kidneys)
Oral herpes (viral infection of mouth)

50-59:

Osteonecrosis of jaw (death of bone of jaw)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Physical disability
Sepsis (a severe blood infection that can lead to organ failure and death)
Thrombocytopenia (decrease of platelets in blood)
Urinary tract infection
Pulmonary oedema (fluid accumulation in the lungs)
Abdominal pain
Cardiac failure congestive
Cellulitis (infection under the skin)

60+:

Cellulitis (infection under the skin)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Respiratory failure (inadequate gas exchange by the respiratory system)
Anaemia (lack of blood)
Anxiety
Atelectasis (partial or complete collapse of the lung)
Back pain
Death
Syncope (loss of consciousness with an inability to maintain postural tone)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)

What are the existing conditions these people have? *

High Blood Pressure: 14 people, 15.05%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 12 people, 12.90%
Nausea (feeling of having an urge to vomit): 12 people, 12.90%
Sedation: 9 people, 9.68%
Pain: 9 people, 9.68%
Constipation: 9 people, 9.68%
Dyspnea (difficult or laboured breathing): 9 people, 9.68%
Cough: 8 people, 8.60%
Multiple Myeloma (cancer of the plasma cells): 8 people, 8.60%
Diarrhea: 7 people, 7.53%

* Approximation only. Some reports may have incomplete information.

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