Zosyn and Zemplar drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zosyn (piperacillin sodium; tazobactam sodium) and Zemplar (paricalcitol). Common drug interactions include erythema among females and anaphylactic reaction among males.

The phase IV clinical study analyzes what interactions people have when they take Zosyn and Zemplar. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.

What is Zosyn?

Zosyn has active ingredients of piperacillin sodium; tazobactam sodium. It is often used in pneumonia. eHealthMe is studying from 10,236 Zosyn users. Check the latest studies of Zosyn.

What is Zemplar?

Zemplar has active ingredients of paricalcitol. It is often used in kidney disease. eHealthMe is studying from 15,494 Zemplar users. Check the latest studies of Zemplar.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 23, 2026

26 people who take Zosyn and Zemplar together, and have interactions are studied.

What are the common drug interactions of Zosyn and Zemplar, by gender? *:

female:

Erythema (redness of the skin)
Weaning failure
Abdominal pain upper
Deformity (disfigurement)
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
Joint range of motion decreased (disease of joint movement)
Joint stiffness
Mobility decreased (ability to move is reduced)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)

male:

Anaphylactic reaction (serious allergic reaction)
Burning sensation
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Dyspnoea (difficult or laboured respiration)
Unresponsive to stimuli

What are the common drug interactions of Zosyn and Zemplar, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Arterial thrombosis limb (formation of a blood clot inside a blood vessel, obstructing the flow of blood through the circulatory system-limb)
Cholecystitis (infection of gallbladder)
Emotional distress
Gallbladder injury
General physical health deterioration (weak health status)
Injury
Pain
Renal failure (kidney dysfunction)

40-49:

n/a

50-59:

Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Diarrhoea
Dizziness
Dyspnoea (difficult or laboured respiration)
Malaise (a feeling of general discomfort or uneasiness)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Muscle spasms (muscle contraction)
Nausea (feeling of having an urge to vomit)
Osteomyelitis (infection of bone)
Abdominal pain

60+:

Abdominal pain
Sepsis (a severe blood infection that can lead to organ failure and death)
Acute respiratory failure
Anal haemorrhage
Clostridial infection (infectious conditions by clostridium bacteria)
Collapse of lung (functional breakdown of lung)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Duodenal ulcer
Dysphagia (a condition in which swallowing is difficult or painful)
Heparin-induced thrombocytopenia

What are the existing conditions these people have? *

High Blood Cholesterol: 15 people, 57.69%
Pain: 14 people, 53.85%
Stress And Anxiety: 13 people, 50.00%
Itching: 13 people, 50.00%
Depression: 12 people, 46.15%
Nuclear Magnetic Resonance Imaging Brain: 12 people, 46.15%
Nausea (feeling of having an urge to vomit): 12 people, 46.15%
Herpes Zoster: 12 people, 46.15%
Gastritis Erosive (a break in the surface layer of the membrane lining the stomach with infection): 12 people, 46.15%
Device Related Infection: 12 people, 46.15%

* Approximation only. Some reports may have incomplete information.

Do you take Zosyn and Zemplar?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously