Zemuron and Zosyn drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zemuron (rocuronium bromide) and Zosyn (piperacillin sodium; tazobactam sodium). Common drug interactions include abdominal infection among females and tachycardia among males.

The phase IV clinical study analyzes what interactions people have when they take Zemuron and Zosyn. It is created by eHealthMe based on reports of 45 people who take the same drugs from the FDA, and is updated regularly.

What is Zemuron?

Zemuron has active ingredients of rocuronium bromide. eHealthMe is studying from 873 Zemuron users. Check the latest studies of Zemuron.

What is Zosyn?

Zosyn has active ingredients of piperacillin sodium; tazobactam sodium. It is often used in pneumonia. eHealthMe is studying from 10,236 Zosyn users. Check the latest studies of Zosyn.

On Aug, 15, 2025

45 people who take Zemuron and Zosyn together, and have interactions are studied.

What are the common drug interactions of Zemuron and Zosyn, by gender? *:

female:

Abdominal infection
Diarrhoea
Enterocutaneous fistula
Hypotension (abnormally low blood pressure)
Injury
Pain
Peritonitis (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs)
Pharyngeal oedema (abnormal accumulation of fluid in the cavities and intercellular spaces of the pharyngeal)
Pleural effusion (water on the lungs)
Small intestinal obstruction (blockage in small intestine)

male:

Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Agitation (state of anxiety or nervous excitement)
Ammonia increased
Apnoea (suspension of external breathing)
Ascites (accumulation of fluid in the abdominal cavity)
Atelectasis (partial or complete collapse of the lung)
Blood triglycerides increased
Chest discomfort
Clonus (series of involuntary, rhythmic, muscular contractions and relaxations)

What are the common drug interactions of Zemuron and Zosyn, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Acinetobacter infection (infection by group of bacteria commonly found in soil and water)
Diarrhoea
Diarrhoea haemorrhagic (bloody diarrhoea)
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Haematoma (collection of blood outside the blood vessels)
Pleural effusion (water on the lungs)
Pyrexia (fever)
Septic shock (shock due to blood infection)
Tooth abscess (pus formation in tooth)

10-19:

Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Hypoxia (low oxygen in tissues)
Neurotoxicity (when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system)
Pericardial effusion (fluid around the heart)
Pyrexia (fever)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Acute lymphocytic leukaemia (cancer of the white blood cells)
Agitation (state of anxiety or nervous excitement)
Ammonia increased
Apnoea (suspension of external breathing)

20-29:

Acute respiratory distress syndrome
Agitation (state of anxiety or nervous excitement)
Back pain
Blood phosphorus decreased
Bradycardia (abnormally slow heart action)
Hyperglycaemia (high blood sugar)
Hypocalcaemia (levels of calcium in blood serum are abnormally low)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)
Leukocytosis (increased white blood cells)

30-39:

Hypotension (abnormally low blood pressure)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Atrioventricular block complete (heart block complete)
Blood triglycerides increased
Bradycardia (abnormally slow heart action)
Cardiac arrest
Cardiogenic shock (inadequate circulation of blood)
Electrocardiogram qt prolonged
Hepatic steatosis (fatty liver disease)
Hepatitis (inflammation of the liver)

40-49:

Gas gangrene (bacterial infection that produces gas within tissues)
Genital abscess (build up of pus in genital)
Groin abscess (pus in groin)
Groin pain
Injury
Intestinal ischaemia (decreased supply of oxygenated blood to the intestines)
Leukocytosis (increased white blood cells)
Lung disorder (lung disease)
Lung infiltration (a substance that normally includes fluid, inflammatory exudates or cells that fill a region of lung)
Lung neoplasm (tumour of lung)

50-59:

Cellulitis (infection under the skin)
Scrotal swelling
Cellulitis of male external genital organ (infection of male genitals soft tissue)
Genital abscess (build up of pus in genital)
Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
Scrotal abscess (pus in scrotum)
Abscess limb (limb infection)
Anal abscess
Gas gangrene (bacterial infection that produces gas within tissues)
Groin abscess (pus in groin)

60+:

Septic shock (shock due to blood infection)
Abdominal infection
Emotional distress
Fear
Injury
Pain
Renal failure (kidney dysfunction)
Renal impairment (severely reduced kidney function)
Renal injury (kidney injury)
Sepsis (a severe blood infection that can lead to organ failure and death)

What are the existing conditions these people have? *

Type 2 Diabetes: 13 people, 28.89%
Hypotension (abnormally low blood pressure): 12 people, 26.67%
Weight Decreased: 11 people, 24.44%
Pain: 11 people, 24.44%
Constipation: 8 people, 17.78%
Nausea (feeling of having an urge to vomit): 8 people, 17.78%
Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 7 people, 15.56%
High Blood Pressure: 7 people, 15.56%
Diabetes: 6 people, 13.33%
Abdominal Infection: 6 people, 13.33%

* Approximation only. Some reports may have incomplete information.

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