Zosyn and Zerbaxa drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zosyn (piperacillin sodium; tazobactam sodium) and Zerbaxa (ceftolozane sulfate; tazobactam sodium). Common drug interactions include abdominal pain among females and leukaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Zosyn and Zerbaxa. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Zosyn?

Zosyn has active ingredients of piperacillin sodium; tazobactam sodium. It is often used in pneumonia. eHealthMe is studying from 10,236 Zosyn users. Check the latest studies of Zosyn.

What is Zerbaxa?

Zerbaxa has active ingredients of ceftolozane sulfate; tazobactam sodium. eHealthMe is studying from 1,018 Zerbaxa users. Check the latest studies of Zerbaxa.

On Feb, 18, 2026

13 people who take Zosyn and Zerbaxa together, and have interactions are studied.

What are the common drug interactions of Zosyn and Zerbaxa, by gender? *:

female:

Abdominal pain
Bacterial infection
Cardiac failure
Cystitis (inflammation of the wall of the bladder)
Diffuse large b-cell lymphoma (cancer of b cells, a type of white blood cell)
Intussusception
Melaena (the passage of black, tarry stools)
Platelet count decreased
Pleural effusion (water on the lungs)
Protein-losing gastroenteropathy (gastrointestinal tract that results in a net loss of protein from the body)

male:

Leukaemia (blood or bone marrow cancer)
Ventricular pre-excitation
Respiratory failure (inadequate gas exchange by the respiratory system)
Drug resistance (reduction in effectiveness of a drug)
Lung disorder (lung disease)
Wound
Death
Dyspnoea (difficult or laboured respiration)
Pneumonia pseudomonal (pseudomonas pneumonia is an infection caused by the microbe known as pseudomonas aeruginosa)
Rash

What are the common drug interactions of Zosyn and Zerbaxa, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Bacterial infection
Cardiac failure
Cystitis (inflammation of the wall of the bladder)
Diffuse large b-cell lymphoma (cancer of b cells, a type of white blood cell)
Intussusception
Melaena (the passage of black, tarry stools)
Platelet count decreased
Pleural effusion (water on the lungs)
Protein-losing gastroenteropathy (gastrointestinal tract that results in a net loss of protein from the body)
Septic shock (shock due to blood infection)

40-49:

n/a

50-59:

Drug resistance (reduction in effectiveness of a drug)
Lung disorder (lung disease)
Wound

60+:

Leukaemia (blood or bone marrow cancer)
Ventricular pre-excitation
Death
Dyspnoea (difficult or laboured respiration)
Pneumonia pseudomonal (pseudomonas pneumonia is an infection caused by the microbe known as pseudomonas aeruginosa)
Respiratory failure (inadequate gas exchange by the respiratory system)

What are the existing conditions these people have? *

Pneumonia: 5 people, 38.46%
Hypokalemia (low potassium): 4 people, 30.77%
Abdominal Infection: 3 people, 23.08%
Sedation: 3 people, 23.08%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 3 people, 23.08%
Pneumonia Pseudomonal (pseudomonas pneumonia is an infection caused by the microbe known as pseudomonas aeruginosa): 3 people, 23.08%
Cystic Fibrosis (disease of the secretary glands): 2 people, 15.38%
Hepatic Function Abnormal: 2 people, 15.38%
Generalised Oedema (swelling all over the body): 2 people, 15.38%
Fever: 2 people, 15.38%

* Approximation only. Some reports may have incomplete information.

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