Zyban and Diphen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zyban (bupropion hydrochloride) and Diphen (diphenhydramine hydrochloride). Common drug interactions include dermatitis among females and suicide attempt among males.

The phase IV clinical study analyzes what interactions people have when they take Zyban and Diphen. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Zyban?

Zyban has active ingredients of bupropion hydrochloride. It is often used in quit smoking. eHealthMe is studying from 8,029 Zyban users. Check the latest studies of Zyban.

What is Diphen?

Diphen has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 115,432 Diphen users. Check the latest studies of Diphen.

On Jul, 13, 2026

20 people who take Zyban and Diphen together, and have interactions are studied.

What are the common drug interactions of Zyban and Diphen, by gender? *:

female:

Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Bronchopneumonia (inflammation of the lungs, arising in the bronchi or bronchioles)
Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)
Dyspnoea (difficult or laboured respiration)
Ecchymosis (a discoloration of the skin resulting from bleeding underneath)
Fatigue (feeling of tiredness)
Gastric erosions (gradual destruction of surface layer of the membrane lining the stomach)
Headache (pain in head)
Hepatic congestion (liver congestion)
Intracranial pressure increased (high pressure inside the skull and thus in the brain tissue and cerebrospinal fluid)

male:

Suicide attempt
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Neoplasm progression (growth of tumour)
Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)
Respiratory tract infection
Somnolence (a state of near-sleep, a strong desire for sleep)
Speech disorder
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Upper respiratory tract infection

What are the common drug interactions of Zyban and Diphen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Bronchopneumonia (inflammation of the lungs, arising in the bronchi or bronchioles)
Ecchymosis (a discoloration of the skin resulting from bleeding underneath)
Gastric erosions (gradual destruction of surface layer of the membrane lining the stomach)
Headache (pain in head)
Hepatic congestion (liver congestion)
Intracranial pressure increased (high pressure inside the skull and thus in the brain tissue and cerebrospinal fluid)
Loss of consciousness
Pleural haemorrhage (bleeding into the membranes around the lungs)
Pulmonary congestion (congestion in the lungs)
Sudden death unexplained

30-39:

Anaphylactoid reaction (type of anaphylaxis that does not involve an allergic reaction but is due to direct mast cell degranulation)
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
Dyspnoea (difficult or laboured respiration)
Rash erythematous (redness of the skin)
Urticaria (rash of round, red welts on the skin that itch intensely)

40-49:

Suicide attempt
Apathy
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Disturbance in attention
Drug ineffective
Fatigue (feeling of tiredness)
Hypertension (high blood pressure)
Palpitations (feelings or sensations that your heart is pounding or racing)
Pruritus (severe itching of the skin)
Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)

50-59:

Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Cardiac disorder
Chest discomfort
Chest pain
Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)
Drug intolerance (drug sensitivity)
Dyspnoea (difficult or laboured respiration)
Pruritus (severe itching of the skin)
Urticaria (rash of round, red welts on the skin that itch intensely)
Wheezing (a high-pitched whistling sound made while you breath)

60+:

Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Angioneurotic oedema (swelling that occurs just beneath the surface of the skin or mucous membranes)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Mouth ulceration (mouth ulcers)
Neoplasm progression (growth of tumour)
Oral pain
Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)
Respiratory tract infection
Somnolence (a state of near-sleep, a strong desire for sleep)
Speech disorder

What are the existing conditions these people have? *

Tumor: 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

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