Zyflo and Oxycontin drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Zyflo (zileuton) and Oxycontin (oxycodone hydrochloride). Common drug interactions include abdominal hernia among females.
The phase IV clinical study analyzes what interactions people have when they take Zyflo and Oxycontin. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.
What is Zyflo?
Zyflo has active ingredients of zileuton. eHealthMe is studying from 1,004 Zyflo users. Check the latest studies of Zyflo.
What is Oxycontin?
Oxycontin has active ingredients of oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 212,533 Oxycontin users. Check the latest studies of Oxycontin.
16 people who take Zyflo and Oxycontin together, and have interactions are studied.

What are the common drug interactions of Zyflo and Oxycontin, by gender? *:
female:
- Abdominal hernia
- Secretion discharge
- Vomiting
- Back disorder
- Blood sodium decreased
- Death
- Diarrhoea
- Intestinal perforation (complete penetration of the wall of the intestine)
- Motion sickness (travel sickness)
- Osteomyelitis (infection of bone)
male:
n/a
What are the common drug interactions of Zyflo and Oxycontin, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
n/a
30-39:
n/a
40-49:
- Diarrhoea
- Pleural effusion (water on the lungs)
- Back disorder
- Death
50-59:
- Urinary tract infection
60+:
- Blood sodium decreased
- Motion sickness (travel sickness)
- Nausea (feeling of having an urge to vomit)
- Pain in extremity
- Post procedural complication
- Vomiting
- Weight decreased
What are the existing conditions these people have? *
- Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 9 people, 56.25%
- Cataplexy (loss of muscle tone accompanied by full conscious awareness): 8 people, 50.00%
- Breast Cancer Female: 3 people, 18.75%
- Neuralgia (pain in one or more nerves): 1 person, 6.25%
- Lung Neoplasm Malignant (cancer tumour of lung): 1 person, 6.25%
- Immunodeficiency: 1 person, 6.25%
- Humoral Immune Defect (impairment of humoral immunity): 1 person, 6.25%
- Fibromyalgia (a long-term condition which causes pain all over the body): 1 person, 6.25%
- Diabetic Neuropathy (neuropathic disorders that are associated with diabetes mellitus): 1 person, 6.25%
- Asthma: 1 person, 6.25%
* Approximation only. Some reports may have incomplete information.
Do you take Zyflo and Oxycontin?
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Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
Browse all drug interactions of Zyflo and Oxycontin:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Zyflo:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Oxycontin:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Zyflo and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Oxycontin and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zHow the study uses the data?
The study uses data from the FDA. It is based on zileuton and oxycodone hydrochloride (the active ingredients of Zyflo and Oxycontin, respectively), and Zyflo and Oxycontin (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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