Zyflo and Pulmicort drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zyflo (zileuton) and Pulmicort (budesonide). Common drug interactions include dry skin among females and pneumonia among males.

The phase IV clinical study analyzes what interactions people have when they take Zyflo and Pulmicort. It is created by eHealthMe based on reports of 98 people who take the same drugs from the FDA, and is updated regularly.

What is Zyflo?

Zyflo has active ingredients of zileuton. eHealthMe is studying from 1,004 Zyflo users. Check the latest studies of Zyflo.

What is Pulmicort?

Pulmicort has active ingredients of budesonide. It is often used in asthma. eHealthMe is studying from 34,980 Pulmicort users. Check the latest studies of Pulmicort.

On Jul, 27, 2026

98 people who take Zyflo and Pulmicort together, and have interactions are studied.

What are the common drug interactions of Zyflo and Pulmicort, by gender? *:

female:

Dry skin
Ear discomfort
Ear pain
Ecchymosis (a discoloration of the skin resulting from bleeding underneath)
Exostosis (formation of new bone on the surface of a bone)
Eye allergy
Fall
Flushing (the warm, red condition of human skin)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Haemorrhage (bleeding)

male:

Pneumonia
Dyspnoea (difficult or laboured respiration)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Wheezing (a high-pitched whistling sound made while you breath)
Alanine aminotransferase increased
Angioedema (rapid swelling of the dermis)
Anxiety
Aptyalism (deficiency or absence of saliva)
Aspartate aminotransferase increased
Blood bilirubin increased

What are the common drug interactions of Zyflo and Pulmicort, by age (0-1 to 60+)? *:

0-1:

Respiratory distress (difficulty in breathing)

2-9:

n/a

10-19:

n/a

20-29:

Maternal exposure during pregnancy (use of substance during pregnancy)
Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)
Crying
Dyspnoea (difficult or laboured respiration)
Influenza
Nausea (feeling of having an urge to vomit)
Premature rupture of membranes
Status asthmaticus (a asthma attack not responds to regular medicines)
Wheezing (a high-pitched whistling sound made while you breath)
Anaemia (lack of blood)

30-39:

Amniotic fluid volume decreased
Maternal exposure during pregnancy (use of substance during pregnancy)
Pancreatitis acute (sudden inflammation of pancreas)
Pharyngeal erythema (pharyngeal redness)
Rhinitis allergic (inflammation of the nasal airways due to allergy)
Abortion spontaneous (naturally occurring miscarriage)
Cough
Flushing (the warm, red condition of human skin)
Labour onset delayed (delayed delivery)
Pregnancy

40-49:

Blood pressure increased
Cataract (clouding of the lens inside the eye)
Overdose
Sinusitis (inflammation of sinus)
Urticaria (rash of round, red welts on the skin that itch intensely)
Dyspnoea (difficult or laboured respiration)
Cough
Increased tendency to bruise (increased tendency to injure the underlying soft tissue or bone)
Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night)
Abdominal pain

50-59:

Dyspnoea (difficult or laboured respiration)
Pneumonia
Throat tightness
Urticaria (rash of round, red welts on the skin that itch intensely)
Blood pressure decreased
Headache (pain in head)
Blindness
Blood pressure increased
Rhinitis allergic (inflammation of the nasal airways due to allergy)
Blood glucose increased

60+:

Cough
Chest discomfort
Malaise (a feeling of general discomfort or uneasiness)
Pneumonia
Rotator cuff repair
Urticaria (rash of round, red welts on the skin that itch intensely)
Dyspnoea (difficult or laboured respiration)
Aptyalism (deficiency or absence of saliva)
Arthralgia (joint pain)
Bedridden

What are the existing conditions these people have? *

Hypersensitivity: 22 people, 22.45%
Blood Immunoglobulin G Decreased: 14 people, 14.29%
Sinus Headache (headache caused by sinus infections): 13 people, 13.27%
Infection: 13 people, 13.27%
Incision Site Pain: 13 people, 13.27%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 13 people, 13.27%
Fibromyalgia (a long-term condition which causes pain all over the body): 11 people, 11.22%
Migraine (headache): 7 people, 7.14%
Seasonal Allergy (allergic condition due to certain season): 6 people, 6.12%
Depression: 6 people, 6.12%

* Approximation only. Some reports may have incomplete information.

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