Zyloprim and Epival drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zyloprim (allopurinol) and Epival (divalproex sodium). Common drug interactions include mental impairment among males.

The phase IV clinical study analyzes what interactions people have when they take Zyloprim and Epival. It is created by eHealthMe based on reports of 32 people who take the same drugs from the FDA, and is updated regularly.

What is Zyloprim?

Zyloprim has active ingredients of allopurinol. It is often used in gout. eHealthMe is studying from 5,638 Zyloprim users. Check the latest studies of Zyloprim.

What is Epival?

Epival has active ingredients of divalproex sodium. It is often used in epilepsy. eHealthMe is studying from 1,088 Epival users. Check the latest studies of Epival.

On Aug, 02, 2026

32 people who take Zyloprim and Epival together, and have interactions are studied.

What are the common drug interactions of Zyloprim and Epival, by gender? *:

female:

n/a

male:

Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition)
General physical health deterioration (weak health status)
Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night)
Productive cough
Wheezing (a high-pitched whistling sound made while you breath)
Agitation (state of anxiety or nervous excitement)
Blood creatinine increased
Blood sodium increased
Blood urea increased
Glomerular filtration rate decreased

What are the common drug interactions of Zyloprim and Epival, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition)
General physical health deterioration (weak health status)
Anxiety
Depressed mood
Irritability
Mood swings (an extreme or rapid change in mood)
Vomiting
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)

30-39:

Drug administration error
Muscle spasms (muscle contraction)
Mydriasis (a dilation of the pupil)
Somnolence (a state of near-sleep, a strong desire for sleep)

40-49:

n/a

50-59:

n/a

60+:

Agitation (state of anxiety or nervous excitement)
Blood creatinine increased
Mania (a state of abnormally elevated or irritable mood)
Pco2 decreased
Poor quality sleep
Red blood cell count decreased
Speech disorder
Urinary tract infection
White blood cell count decreased
Blood triglycerides increased

What are the existing conditions these people have? *

Affective Disorder (mental disorder): 12 people, 37.50%
Autism Spectrum Disorder (developmental disabilities that can cause significant social, communication and behavioural challenges): 10 people, 31.25%
Hypertonic Bladder (bladder-storage function that causes a sudden urge to urinate): 7 people, 21.88%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 21.88%
Depression: 7 people, 21.88%
Stress And Anxiety: 5 people, 15.62%
Bipolar Disorder (mood disorder): 3 people, 9.38%
Urinary Tract Infection: 2 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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