Zymar and Vioxx drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zymar (gatifloxacin) and Vioxx (rofecoxib). Common drug interactions include abdominal distension among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Zymar and Vioxx. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Zymar?

Zymar has active ingredients of gatifloxacin. eHealthMe is studying from 692 Zymar users. Check the latest studies of Zymar.

What is Vioxx?

Vioxx has active ingredients of rofecoxib. It is often used in arthritis. eHealthMe is studying from 110,130 Vioxx users. Check the latest studies of Vioxx.

On Jul, 06, 2026

18 people who take Zymar and Vioxx together, and have interactions are studied.

What are the common drug interactions of Zymar and Vioxx, by gender? *:

female:

Abdominal distension
Abdominal pain upper
Acute coronary syndrome (acute chest pain and other symptoms that happen because the heart does not get blood)
Alopecia (absence of hair from areas of the body)
Anaemia (lack of blood)
Anaemia of malignant disease
Anxiety
Barrett's oesophagus (barrett's oesophagus is a disorder in which the lining of the oesophagus (the tube that carries food from the throat to the stomach) is damaged by stomach acid and changed to a lining similar to that of the stomach)
Bone deformity
Bone disorder

male:

Anxiety
Hypertension (high blood pressure)
Osteomyelitis (infection of bone)
Anaemia (lack of blood)
Back pain
Decreased appetite
Fatigue (feeling of tiredness)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Hyperglycaemia (high blood sugar)
Leukocytosis (increased white blood cells)

What are the common drug interactions of Zymar and Vioxx, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Cardiac failure congestive
Depression
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)

50-59:

Jaw fracture
Osteomyelitis (infection of bone)
Osteonecrosis (death of bone)
Pain in jaw
Pathological fracture (broken bone caused by disease)
Speech disorder
Tooth extraction
Toothache (tooth pain)
Blood cholesterol increased
Cataract (clouding of the lens inside the eye)

60+:

Arthralgia (joint pain)
Back pain
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dehydration (dryness resulting from the removal of water)
Depression
Fatigue (feeling of tiredness)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Hyperlipidaemia (presence of excess lipids in the blood)
Insomnia (sleeplessness)
Muscular weakness (muscle weakness)

What are the existing conditions these people have? *

Osteoarthritis (a joint disease caused by cartilage loss in a joint): 3 people, 16.67%
High Blood Pressure: 3 people, 16.67%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 11.11%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 1 person, 5.56%
Heart Rate Irregular: 1 person, 5.56%
Diabetic Gastroparesis (paralysis of the muscles of the stomach caused by diabetes): 1 person, 5.56%
Depression: 1 person, 5.56%
Bone Disorder: 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

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