Zyprexa and Cleocin drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Zyprexa (olanzapine) and Cleocin (clindamycin phosphate). Common drug interactions include reticulocytosis among females and amnesia among males.
The phase IV clinical study analyzes what interactions people have when they take Zyprexa and Cleocin. It is created by eHealthMe based on reports of 30 people who take the same drugs from the FDA, and is updated regularly.
What is Zyprexa?
Zyprexa has active ingredients of olanzapine. It is often used in bipolar disorder. eHealthMe is studying from 64,724 Zyprexa users. Check the latest studies of Zyprexa.
What is Cleocin?
Cleocin has active ingredients of clindamycin phosphate. It is often used in infection. eHealthMe is studying from 3,940 Cleocin users. Check the latest studies of Cleocin.
eHealthMe: drug outcomes in the real world
eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.
30 people who take Zyprexa and Cleocin together, and have interactions are studied.

What are the common drug interactions of Zyprexa and Cleocin, by gender? *:
female:
- Reticulocytosis (a condition where there is an increase in reticulocytes)
- Self mutilation
- Shoplifting
- Sinus bradycardia (an unusually slow heartbeat due to heart disease)
- Suicidal ideation
- Swelling face
- Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue)
- Tachycardia (a heart rate that exceeds the range of 100 beats/min)
- Theft
- Tremor (trembling or shaking movements in one or more parts of your body)
male:
- Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
- Balance disorder
- Abdominal distension
- Asthenia (weakness)
- Blood glucose increased
- Cellulitis (infection under the skin)
- Colitis (inflammation of colon)
- Dehydration (dryness resulting from the removal of water)
- Diabetes mellitus inadequate control
- Diarrhoea
What are the common drug interactions of Zyprexa and Cleocin, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
- Grand mal convulsion (a type of generalized seizure that affects the entire brain)
20-29:
n/a
30-39:
- Anhedonia (inability to experience pleasure from activities usually found enjoyable)
- Bipolar i disorder (mood disorder that is characterized by at least one manic or mixed episode)
- Compulsive sexual behaviour (unable to manage his/her sexual behaviour)
- Compulsive shopping
- Disability
- Eating disorder
- Emotional distress
- Epistaxis (bleed from the nose)
- Fibromyalgia (a long-term condition which causes pain all over the body)
- Impulse-control disorder
40-49:
- Muscle strain (an injury to a muscle in which the muscle fibres tear)
- Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
- Myalgia (muscle pain)
- Myositis (inflammation of the muscles)
- Neck pain
- Pain
- Pain in extremity
- Peripheral swelling
- Road traffic accident
- Spinal pain (pain in spine)
50-59:
- Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
- Balance disorder
- Cerebellar atrophy (degeneration of the section of the brain responsible for balance, voluntary muscle movements)
- Cerebral atrophy (decrement in size of brain)
- Speech disorder
- Spinal osteoarthritis (joint cartilage loss in spine)
- Chronic kidney disease
- Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night)
- Poor quality sleep
- Renal failure (kidney dysfunction)
60+:
- Blood creatinine increased
- Asthenia (weakness)
- Diarrhoea
- Drug ineffective
- Heart rate irregular
- Hyperbilirubinaemia (excess of bilirubin in the blood)
- Hypokalaemia (low potassium)
- Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
- Liver disorder (liver diseases)
- Musculoskeletal chest pain (pain in chest muscle or nerve or bones)
What are the existing conditions these people have? *
- Pain: 7 people, 23.33%
- High Blood Pressure: 7 people, 23.33%
- Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 20.00%
- Seizures (abnormal excessive or synchronous neuronal activity in the brain): 5 people, 16.67%
- Sleep Disorder: 5 people, 16.67%
- Nausea (feeling of having an urge to vomit): 4 people, 13.33%
- Muscle Spasms (muscle contraction): 4 people, 13.33%
- Itching: 4 people, 13.33%
- Stress And Anxiety: 3 people, 10.00%
- Constipation: 3 people, 10.00%
* Approximation only. Some reports may have incomplete information.
Do you take Zyprexa and Cleocin?
- Personalize this study to your gender, age, symptoms and drugs
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Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
Browse all drug interactions of Zyprexa and Cleocin:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Zyprexa:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Cleocin:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Zyprexa and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Cleocin and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- Gupta SK, Shwetank B, "Reversible bilateral sensori-neural hearing loss due to olanzapine in a male suffering from bipolar affective disorder", Indian journal of pharmacology, 2014 Jan .
- Og?odek E, Szota A, Araszkiewicz A, "Olanzapine-induced neuroleptic malignant syndrome after 10 years of treatment", Aust NZJ Psychiatry, 2013 Oct .
- Gupta SK, Shwetank B, "Reversible bilateral sensori-neural hearing loss due to olanzapine in a male suffering from bipolar affective disorder", Indian journal of pharmacology, 2014 Jan .
- Og?odek E, Szota A, Araszkiewicz A, "Olanzapine-induced neuroleptic malignant syndrome after 10 years of treatment", Aust NZJ Psychiatry, 2013 Oct .
How the study uses the data?
The study uses data from the FDA. It is based on olanzapine and clindamycin phosphate (the active ingredients of Zyprexa and Cleocin, respectively), and Zyprexa and Cleocin (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
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