Zyprexa and Macrobid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zyprexa (olanzapine) and Macrobid (nitrofurantoin; nitrofurantoin, macrocrystalline). Common drug interactions include blood calcium decreased among females and abnormal behaviour among males.

The phase IV clinical study analyzes what interactions people have when they take Zyprexa and Macrobid. It is created by eHealthMe based on reports of 48 people who take the same drugs from the FDA, and is updated regularly.

What is Zyprexa?

Zyprexa has active ingredients of olanzapine. It is often used in bipolar disorder. eHealthMe is studying from 64,724 Zyprexa users. Check the latest studies of Zyprexa.

What is Macrobid?

Macrobid has active ingredients of nitrofurantoin; nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. eHealthMe is studying from 9,215 Macrobid users. Check the latest studies of Macrobid.

On Jul, 12, 2026

48 people who take Zyprexa and Macrobid together, and have interactions are studied.

What are the common drug interactions of Zyprexa and Macrobid, by gender? *:

female:

Blood calcium decreased
Bowel sounds
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardiac failure congestive
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Weight increased
Overdose
Hypertension (high blood pressure)
Neuropathy peripheral (surface nerve damage)
Hyperglycaemia (high blood sugar)

male:

Abnormal behaviour
Aggression
Drug exposure during pregnancy
Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
Maternal exposure during pregnancy (use of substance during pregnancy)
Pulmonary artery stenosis congenital (congenital -narrowing (stenosis) that occurs in the lung artery)
Urinary tract infection staphylococcal
Dementia (madness)
Insomnia (sleeplessness)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)

What are the common drug interactions of Zyprexa and Macrobid, by age (0-1 to 60+)? *:

0-1:

Muscular weakness (muscle weakness)
Tremor (trembling or shaking movements in one or more parts of your body)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Neoplasm malignant (cancer tumour)

2-9:

n/a

10-19:

n/a

20-29:

Alanine aminotransferase increased
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Aspartate aminotransferase increased
Bile duct stone
Cholecystitis chronic (long lasting infection of gallbladder)
Culture urine positive
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Electrocardiogram qt prolonged
Emotional distress
Gallbladder disorder

30-39:

Insomnia (sleeplessness)
Abdominal pain
Back pain
Bipolar i disorder (mood disorder that is characterized by at least one manic or mixed episode)
Blood pressure increased
Chest pain
Decreased appetite
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dyslipidaemia (abnormal amount of lipids)
Dyspnoea (difficult or laboured respiration)

40-49:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Muscular weakness (muscle weakness)
Neoplasm malignant (cancer tumour)
Pain
Tremor (trembling or shaking movements in one or more parts of your body)
Abdominal pain
Asthenia (weakness)
Diabetic retinopathy (damage to the retina caused by complications of diabetes)
Type 2 diabetes mellitus

50-59:

Abnormal behaviour
Ataxia (loss of full control of bodily movements)
Dysarthria (speech disorder)
Gait disturbance
Judgement impaired
Parkinsonism (degenerative disorder of the central nervous system characterized by tremor and impaired muscular coordination)
Abdominal pain
Acute sinusitis
Adverse drug reaction
Angina unstable (chest pain due to ischemia of the heart muscle- unstable)

60+:

Chronic kidney disease
Anaemia (lack of blood)
Insomnia (sleeplessness)
Aortic aneurysm (enlargement of an aortic artery caused by a weakening of the artery wall)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Back pain
Blood calcium decreased
Blood pressure increased
Bowel sounds
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)

What are the existing conditions these people have? *

Depression: 11 people, 22.92%
Stress And Anxiety: 10 people, 20.83%
High Blood Pressure: 9 people, 18.75%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 16.67%
Pain: 8 people, 16.67%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 6 people, 12.50%
Insomnia (sleeplessness): 6 people, 12.50%
Sleep Disorder: 6 people, 12.50%
Asthma: 5 people, 10.42%
Infection: 5 people, 10.42%

* Approximation only. Some reports may have incomplete information.

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