Zyprexa and Phentermine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zyprexa (olanzapine) and Phentermine (phentermine hydrochloride). Common drug interactions include systemic lupus erythematosus among females and abdominal distension among males.

The phase IV clinical study analyzes what interactions people have when they take Zyprexa and Phentermine. It is created by eHealthMe based on reports of 56 people who take the same drugs from the FDA, and is updated regularly.

What is Zyprexa?

Zyprexa has active ingredients of olanzapine. It is often used in bipolar disorder. eHealthMe is studying from 64,724 Zyprexa users. Check the latest studies of Zyprexa.

What is Phentermine?

Phentermine has active ingredients of phentermine hydrochloride. It is often used in weight loss. eHealthMe is studying from 19,870 Phentermine users. Check the latest studies of Phentermine.

On Jul, 20, 2026

56 people who take Zyprexa and Phentermine together, and have interactions are studied.

Zyprexa and Phentermine drug interactions.

What are the common drug interactions of Zyprexa and Phentermine, by gender? *:

female:

Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue)
Tendonitis (a condition that causes pain and swelling of tendons)
Therapeutic response unexpected
Thyroid disorder (thyroid diseases)
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Hyperlipidaemia (presence of excess lipids in the blood)
Schizophrenia (a mental disorder characterized by a breakdown of thought processes)
Abnormal behaviour
Agitation (state of anxiety or nervous excitement)
Anger

male:

Abdominal distension
Abdominal pain
Nausea (feeling of having an urge to vomit)
Renal cyst (kidney cyst)
Tardive dyskinesia (a disorder that involves involuntary movements)
Weight increased
Arrhythmia (irregular heartbeat)
Cardiac disorder
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Fatigue (feeling of tiredness)

What are the common drug interactions of Zyprexa and Phentermine, by age (0-1 to 60+)? *:

0-1:

Ankle fracture
Suicidal ideation
Type 2 diabetes mellitus

2-9:

n/a

10-19:

n/a

20-29:

Seizure (abnormal excessive or synchronous neuronal activity in the brain)

30-39:

Renal failure (kidney dysfunction)
Chronic kidney disease
Urinary tract infection
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Bipolar i disorder (mood disorder that is characterized by at least one manic or mixed episode)
Fibromyalgia (a long-term condition which causes pain all over the body)
Hypertension (high blood pressure)
Mania (a state of abnormally elevated or irritable mood)
Nausea (feeling of having an urge to vomit)
Neuropathy peripheral (surface nerve damage)

40-49:

Blood triglycerides increased
Cardiac disorder
Chronic kidney disease
Confusional state
Deafness
Delirium (wild excitement)
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Dizziness postural
Drug ineffective
Enterocele (hernia of the intestine through the vagina)

50-59:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Hunger
Insomnia (sleeplessness)
Merycism (a rare disease in which food is chewed, swallowed, and then returned to the mouth and chewed again)
Muscle spasms (muscle contraction)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
Periodic limb movement disorder
Pseudodementia (severe form of depression that results from a progressive brain disorder in which cognitive changes mimic those of dementia)
Sleep paralysis (waking up and unable to move or speak)

60+:

Pneumonia

What are the existing conditions these people have? *

Depression: 11 people, 19.64%
Sleep Disorder: 9 people, 16.07%
Pain: 9 people, 16.07%
Stress And Anxiety: 7 people, 12.50%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 7 people, 12.50%
Insomnia (sleeplessness): 7 people, 12.50%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 10.71%
Weight Loss: 3 people, 5.36%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 5.36%
Itching: 3 people, 5.36%

* Approximation only. Some reports may have incomplete information.

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