Zyprexa and Septra drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zyprexa (olanzapine) and Septra (sulfamethoxazole; trimethoprim). Common drug interactions include heart rate increased among females and weight increased among males.

The phase IV clinical study analyzes what interactions people have when they take Zyprexa and Septra. It is created by eHealthMe based on reports of 62 people who take the same drugs from the FDA, and is updated regularly.

What is Zyprexa?

Zyprexa has active ingredients of olanzapine. It is often used in bipolar disorder. eHealthMe is studying from 64,724 Zyprexa users. Check the latest studies of Zyprexa.

What is Septra?

Septra has active ingredients of sulfamethoxazole; trimethoprim. It is often used in urinary tract infection. eHealthMe is studying from 10,280 Septra users. Check the latest studies of Septra.

On Jul, 12, 2026

62 people who take Zyprexa and Septra together, and have interactions are studied.

What are the common drug interactions of Zyprexa and Septra, by gender? *:

female:

Heart rate increased
Increased appetite
Increased bronchial secretion
Influenza
Laryngitis (inflammation of the larynx)
Oral herpes (viral infection of mouth)
Pruritus (severe itching of the skin)
Rash erythematous (redness of the skin)
Respiratory tract infection
Sputum discoloured

male:

Weight increased
Sedation
Psychotic disorder
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Agitation (state of anxiety or nervous excitement)
Epistaxis (bleed from the nose)
Apathy
Appetite increased (increased appetite is when you want to eat much more often or in larger quantities than your body requires)
Fatigue (feeling of tiredness)
Hallucination (an experience involving the perception of something not present)

What are the common drug interactions of Zyprexa and Septra, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Mydriasis (a dilation of the pupil)
Photophobia (extreme sensitivity to light)
Pupillary reflex impaired

10-19:

Appetite increased (increased appetite is when you want to eat much more often or in larger quantities than your body requires)
Fatigue (feeling of tiredness)
Psychotic disorder
Sedation
Weight increased
Schizophrenia (a mental disorder characterized by a breakdown of thought processes)
Chest pain
Delusion (a false belief or opinion)
Delusional disorder, paranoid type (a type of serious mental illness involving psychosis)
Hallucination, auditory (perceiving sounds without auditory stimulus)

20-29:

Metabolic disorder (an abnormal function and pattern of body fat. insulin resistance refers to the diminished ability of cells to respond to the action of insulin in promoting the transport of the sugar glucose, from blood into muscles and other tissues)
Pancreatitis haemorrhagic (inflammation of pancreas with bleeding)
Headache (pain in head)
Drug level increased
Insomnia (sleeplessness)
Abdominal pain
Abnormal behaviour
Asthenia (weakness)
Blood chloride increased
Blood glucose increased

30-39:

Herpes zoster
Agitation (state of anxiety or nervous excitement)
Anaemia (lack of blood)
Aplasia pure red cell (type of anaemia affecting the precursors to red blood cells but not to white blood cells)
Dyspnoea (difficult or laboured respiration)
Electrocardiogram qt corrected interval prolonged
Electrocardiogram qt prolonged
Epistaxis (bleed from the nose)
Herpes simplex (herpes simplex is a common viral infection)
Malaise (a feeling of general discomfort or uneasiness)

40-49:

Weight increased
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Obesity (having too much body fat)
Blood cholesterol increased
Blood triglycerides increased
Haematuria (presence of blood in urine)
Hunger
Metabolic disorder (an abnormal function and pattern of body fat. insulin resistance refers to the diminished ability of cells to respond to the action of insulin in promoting the transport of the sugar glucose, from blood into muscles and other tissues)
Sedation
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)

50-59:

Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Upper respiratory tract congestion
Wound
Breath sounds
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Intra-abdominal haemorrhage (intra-abdominal bleeding)
Streptococcal bacteraemia (a bacterial infection of blood)
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Viral upper respiratory tract infection
Anaemia (lack of blood)

60+:

Acute myocardial infarction (acute heart attack)
Angina unstable (chest pain due to ischemia of the heart muscle- unstable)
Loss of consciousness
Renal failure acute (rapid kidney dysfunction)
Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)
Tremor (trembling or shaking movements in one or more parts of your body)
Vascular dementia (vascular dementia is a general term describing problems with reasoning, planning, judgment, memory and other thought)
Ventricular hypertrophy (enlargement of ventricles (lower chambers) in the heart)
Atherosclerosis (disorder of the arteries)
Blood cholesterol increased

What are the existing conditions these people have? *

Graft Versus Host Disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body): 6 people, 9.68%
Tumor: 5 people, 8.06%
Pain: 5 people, 8.06%
Asthma: 4 people, 6.45%

* Approximation only. Some reports may have incomplete information.

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