Zyvox and Amikin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zyvox (linezolid) and Amikin (amikacin sulfate). Common drug interactions include hepatomegaly among females and septic shock among males.

The phase IV clinical study analyzes what interactions people have when they take Zyvox and Amikin. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Zyvox?

Zyvox has active ingredients of linezolid. It is often used in mrsa infection. eHealthMe is studying from 9,399 Zyvox users. Check the latest studies of Zyvox.

What is Amikin?

Amikin has active ingredients of amikacin sulfate. eHealthMe is studying from 528 Amikin users. Check the latest studies of Amikin.

On Jul, 05, 2026

12 people who take Zyvox and Amikin together, and have interactions are studied.

What are the common drug interactions of Zyvox and Amikin, by gender? *:

female:

Hepatomegaly (abnormal enlargement of the liver)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Thrombocytopenia (decrease of platelets in blood)
Venoocclusive disease (small veins in the liver are obstructed)
Weight increased
Anaemia (lack of blood)
Ascites (accumulation of fluid in the abdominal cavity)
Budd chiari syndrome (problem that results from blood clotting in the veins flowing out of the liver (hepatic veins))
Cardiac failure
Drug toxicity

male:

Septic shock (shock due to blood infection)
Pneumonia
Jaundice cholestatic
Lower respiratory tract infection
Pseudomonal sepsis (pseudomonas infections are diseases caused by a bacterium from the genus pseudomonas)
Pseudomonas infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa)
Shock haemorrhagic (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin due to excess bleeding)
Sputum culture positive
Thrombocytopenia (decrease of platelets in blood)
Acinetobacter infection (infection by group of bacteria commonly found in soil and water)

What are the common drug interactions of Zyvox and Amikin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Thrombocytopenia (decrease of platelets in blood)
Anaemia (lack of blood)
Ascites (accumulation of fluid in the abdominal cavity)
Cardiac failure
Drug toxicity
Lower respiratory tract infection
Oedema (fluid collection in tissue)
Overdose
Pericardial effusion (fluid around the heart)

10-19:

n/a

20-29:

n/a

30-39:

Budd chiari syndrome (problem that results from blood clotting in the veins flowing out of the liver (hepatic veins))
Cytomegalovirus infection
Drug ineffective
Enterococcal sepsis
Histiocytosis haematophagic
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Jaundice cholestatic
Pseudomonal sepsis (pseudomonas infections are diseases caused by a bacterium from the genus pseudomonas)
Pseudomonas infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa)
Septic shock (shock due to blood infection)

40-49:

n/a

50-59:

n/a

60+:

Septic shock (shock due to blood infection)
Pneumonia
Acinetobacter infection (infection by group of bacteria commonly found in soil and water)
Candidiasis (candidiasis or thrush is a fungal infection)
Fungal sepsis (whole body infection by fungus)
Sputum culture positive
Thrombocytopenia (decrease of platelets in blood)

What are the existing conditions these people have? *

Scedosporium Infection (a filamentous fungus which occasionally causes infections in humans): 3 people, 25.00%
Systemic Candida (whole body fungal infection): 2 people, 16.67%
Pneumonia: 2 people, 16.67%
Tuberculosis (a bacterial infection by mycobacterium tuberculosis): 1 person, 8.33%
Stenotrophomonas Infection: 1 person, 8.33%
Sepsis (a severe blood infection that can lead to organ failure and death): 1 person, 8.33%
Pathogen Resistance: 1 person, 8.33%
Nosocomial Infection (infection from hospital): 1 person, 8.33%
Mycobacterial Infection: 1 person, 8.33%
Fungaemia (fungi circulate in the blood): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

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