Zyvox and Amitiza drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zyvox (linezolid) and Amitiza (lubiprostone). Common drug interactions include rash among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Zyvox and Amitiza. It is created by eHealthMe based on reports of 31 people who take the same drugs from the FDA, and is updated regularly.

What is Zyvox?

Zyvox has active ingredients of linezolid. It is often used in mrsa infection. eHealthMe is studying from 9,399 Zyvox users. Check the latest studies of Zyvox.

What is Amitiza?

Amitiza has active ingredients of lubiprostone. It is often used in constipation. eHealthMe is studying from 10,567 Amitiza users. Check the latest studies of Amitiza.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

31 people who take Zyvox and Amitiza together, and have interactions are studied.

What are the common drug interactions of Zyvox and Amitiza, by gender? *:

female:

Rash
Anxiety
Diarrhoea
Adverse drug reaction
Dizziness
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Insomnia (sleeplessness)
Nausea (feeling of having an urge to vomit)
Tremor (trembling or shaking movements in one or more parts of your body)
Cholecystitis acute (rapid infection of gallbladder)

male:

Chronic kidney disease
Decreased appetite
Burning sensation
Emotional distress
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Interstitial lung disease
Irritability
Joint injury
Limb injury
Nephrogenic anaemia (anaemia due to kidney disease)

What are the common drug interactions of Zyvox and Amitiza, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Blood alkaline phosphatase increased
Bone density decreased
Burning sensation
Chronic kidney disease
Emotional distress
Irritability
Joint injury
Limb injury

40-49:

Dental caries
Dystonia (abnormal muscle tone)
Facial bones fracture (bone fracture of face)
Fall
Pneumonia
Tremor (trembling or shaking movements in one or more parts of your body)

50-59:

Chronic kidney disease
Renal failure (kidney dysfunction)
Renal injury (kidney injury)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)

60+:

Cholecystitis acute (rapid infection of gallbladder)
Depression
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Febrile neutropenia (fever with reduced white blood cells)
Sepsis (a severe blood infection that can lead to organ failure and death)
Decreased appetite
Malaise (a feeling of general discomfort or uneasiness)
Diarrhoea
Inappropriate antidiuretic hormone secretion
Interstitial lung disease

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 19.35%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 5 people, 16.13%
Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 4 people, 12.90%
Infection: 4 people, 12.90%
High Blood Pressure: 4 people, 12.90%
Stress And Anxiety: 3 people, 9.68%
Irritable Bowel Syndrome: 2 people, 6.45%
Infectious Pleural Effusion (infectious fluid in the lung): 2 people, 6.45%
Multiple Allergies (allergy to multiple agents): 2 people, 6.45%
Indigestion: 2 people, 6.45%

* Approximation only. Some reports may have incomplete information.

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