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Zyvox and Hydrochlorothiazide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zyvox (linezolid) and Hydrochlorothiazide (hydrochlorothiazide). Common drug interactions include renal failure among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Zyvox and Hydrochlorothiazide. It is created by eHealthMe based on reports of 93 people who take the same drugs from the FDA, and is updated regularly.

What is Zyvox?

Zyvox has active ingredients of linezolid. It is often used in mrsa infection. eHealthMe is studying from 9,399 Zyvox users. Check the latest studies of Zyvox.

What is Hydrochlorothiazide?

Hydrochlorothiazide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 182,194 Hydrochlorothiazide users. Check the latest studies of Hydrochlorothiazide.

On Jul, 15, 2026

93 people who take Zyvox and Hydrochlorothiazide together, and have interactions are studied.

Zyvox and Hydrochlorothiazide drug interactions.

What are the common drug interactions of Zyvox and Hydrochlorothiazide, by gender? *:

female:

  1. Renal failure (kidney dysfunction)
  2. Staphylococcal infection (an infection with staphylococcus bacteria)
  3. Vomiting
  4. Weight decreased
  5. Chronic kidney disease
  6. Diarrhoea
  7. Osteonecrosis (death of bone)
  8. Spinal decompression (relief of pressure on one or many pinched nerves (neural impingement) of the spinal column)
  9. Swelling face
  10. Dry mouth

male:

  1. Chronic kidney disease
  2. Dyspnoea (difficult or laboured respiration)
  3. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  4. Anxiety
  5. Asthenia (weakness)
  6. Chest discomfort
  7. Cough
  8. Diarrhoea
  9. Dry skin
  10. Emotional distress

What are the common drug interactions of Zyvox and Hydrochlorothiazide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

  1. Psoriasis (immune-mediated disease that affects the skin)
  2. Therapeutic response unexpected

20-29:

  1. Disease recurrence
  2. Enterococcal infection

30-39:

  1. Renal failure (kidney dysfunction)
  2. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  3. Anxiety
  4. Chronic kidney disease
  5. Depression
  6. Device related infection
  7. Emotional distress
  8. Hyperkalaemia (damage to or disease of the kidney)
  9. Hyperparathyroidism (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium)
  10. Pain

40-49:

  1. Ileus (a painful obstruction of the ileum or other part of the intestine)
  2. Pneumonia
  3. Septic shock (shock due to blood infection)
  4. Chronic kidney disease
  5. Renal failure (kidney dysfunction)
  6. Dizziness
  7. Gastric haemorrhage (bleeding stomach)
  8. Haemoglobin decreased
  9. Hypoaesthesia (reduced sense of touch or sensation)
  10. Hypotension (abnormally low blood pressure)

50-59:

  1. Disability
  2. Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
  3. Facial pain
  4. Fracture
  5. Hip fracture
  6. Humerus fracture (injury to the upper arm bone)
  7. Hydrocephalus (water on the brain)
  8. Hypoaesthesia (reduced sense of touch or sensation)
  9. Injury
  10. Intervertebral disc protrusion (spinal disc protrusion)

60+:

  1. Anxiety
  2. Vomiting
  3. Depression
  4. Dizziness
  5. Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
  6. Anaemia (lack of blood)
  7. Abdominal discomfort
  8. Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
  9. Bradycardia (abnormally slow heart action)
  10. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)

What are the existing conditions these people have? *

  1. High Blood Cholesterol: 14 people, 15.05%
  2. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 11 people, 11.83%
  3. Pain: 10 people, 10.75%
  4. Neoplasm Malignant (cancer tumour): 10 people, 10.75%
  5. Staphylococcal Infection (an infection with staphylococcus bacteria): 8 people, 8.60%
  6. Stress And Anxiety: 7 people, 7.53%
  7. Pneumonia: 7 people, 7.53%
  8. Diabetes: 7 people, 7.53%
  9. Cardiac Disorder: 7 people, 7.53%
  10. Constipation: 6 people, 6.45%

* Approximation only. Some reports may have incomplete information.

Do you take Zyvox and Hydrochlorothiazide?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Zyvox and Hydrochlorothiazide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Zyvox:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Hydrochlorothiazide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Zyvox and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Hydrochlorothiazide and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on linezolid and hydrochlorothiazide (the active ingredients of Zyvox and Hydrochlorothiazide, respectively), and Zyvox and Hydrochlorothiazide (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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