Zyvox and Protamine sulfate drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Zyvox (linezolid) and Protamine sulfate (protamine sulfate). Common drug interactions include renal failure among females and anhedonia among males.
The phase IV clinical study analyzes what interactions people have when they take Zyvox and Protamine sulfate. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.
What is Zyvox?
Zyvox has active ingredients of linezolid. It is often used in mrsa infection. eHealthMe is studying from 9,399 Zyvox users. Check the latest studies of Zyvox.
What is Protamine sulfate?
Protamine sulfate has active ingredients of protamine sulfate. eHealthMe is studying from 3,292 Protamine sulfate users. Check the latest studies of Protamine sulfate.
11 people who take Zyvox and Protamine sulfate together, and have interactions are studied.

What are the common drug interactions of Zyvox and Protamine Sulfate, by gender? *:
female:
- Renal failure (kidney dysfunction)
- Anxiety
- Fear
- Pain
- Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
- Anhedonia (inability to experience pleasure from activities usually found enjoyable)
- Death
- Depression
- Injury
- Renal injury (kidney injury)
male:
- Anhedonia (inability to experience pleasure from activities usually found enjoyable)
- Anxiety
- Stress
- Death
- Emotional distress
- Fear
- Injury
- Pain
- Renal failure (kidney dysfunction)
- Renal impairment (severely reduced kidney function)
What are the common drug interactions of Zyvox and Protamine Sulfate, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
n/a
30-39:
- Anhedonia (inability to experience pleasure from activities usually found enjoyable)
- Anxiety
- Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
- Death
- Depression
- Fear
- Injury
- Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
- Pain
- Renal failure (kidney dysfunction)
40-49:
- Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
- Drug ineffective
- Inflammation
- Malignant neoplasm progression (cancer tumour came back)
- Nausea (feeling of having an urge to vomit)
- Spinal pain (pain in spine)
- Cardiac failure congestive
- Hypertension (high blood pressure)
- Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
- Obstruction
50-59:
n/a
60+:
- Anxiety
- Fear
- Stress
- Cardiogenic shock (inadequate circulation of blood)
- Depression
- Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
- Anaphylactic reaction (serious allergic reaction)
- Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)
- Cardiac arrest
- Hypotension (abnormally low blood pressure)
What are the existing conditions these people have? *
- Coronary Ostial Stenosis (narrowing of the mouths of the coronary arteries): 2 people, 18.18%
- Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 2 people, 18.18%
- Urinary Tract Infection: 1 person, 9.09%
- Nausea (feeling of having an urge to vomit): 1 person, 9.09%
- Lung Carcinoma Cell Type Unspecified Stage 0 (the lung cancer has not spread beyond the inner lining of the lung): 1 person, 9.09%
- Diabetes: 1 person, 9.09%
- Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 1 person, 9.09%
- Activated Partial Thromboplastin Time Prolonged: 1 person, 9.09%
* Approximation only. Some reports may have incomplete information.
Do you take Zyvox and Protamine sulfate?
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Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
- Zyvox (9,399 reports)
- Protamine sulfate (3,292 reports)
Browse all drug interactions of Zyvox and Protamine sulfate:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Zyvox:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Protamine sulfate:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Zyvox and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Protamine sulfate and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zHow the study uses the data?
The study uses data from the FDA. It is based on linezolid and protamine sulfate (the active ingredients of Zyvox and Protamine sulfate, respectively), and Zyvox and Protamine sulfate (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
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