A study for a 65 year old woman who takes Cytomel, Estradiol, Progesterone (an AI-powered real world drug study)
Summary:
1,048 females aged 65 (±5) who take the same drugs and have adverse effects are studied. This is a phase IV clinical study for a 65 year old female patient who has Hypothyroidism, Menopause. The study is created by eHealthMe based on reports from sources including the FDA.
1,048 females aged 65 (±5) who take Cytomel, Estradiol, Progesterone and have adverse effects are studied.
Number of reports submitted per year:

Information of the patient in this study:
- Age: 65
- Gender: female
What are the drugs?
- Cytomel has active ingredients of liothyronine sodium. It is often used in hypothyroidism. eHealthMe is studying from 7,595 Cytomel users. Check the latest studies of Cytomel.
- Estradiol has active ingredients of estradiol. It is often used in menopause. eHealthMe is studying from 18,986 Estradiol users. Check the latest studies of Estradiol.
- Progesterone has active ingredients of progesterone. It is often used in menopause. eHealthMe is studying from 21,021 Progesterone users. Check the latest studies of Progesterone.
What are the conditions?
- Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development) is found to be associated with 1,617 drugs and 2,600 conditions by eHealthMe. Check the latest studies of Hypothyroidism.
- Menopause (end of monthly cycles in women) is found to be associated with 400 drugs and 488 conditions by eHealthMe. Check the latest studies of Menopause.
What are the adverse effects?
- Tinnitus (a ringing in the ears) is found to be associated with 1,668 drugs and 3,065 conditions by eHealthMe. Check the latest studies of Tinnitus.
- Lumbar spinal stenosis (a medical condition in which the spinal canal narrows and compresses the spinal cord and nerves at the level of the lumbar bone) is found to be associated with 765 drugs and 694 conditions by eHealthMe. Check the latest studies of Lumbar spinal stenosis.
- Benign positional vertigo (disorder arising in the inner ear cause vertigo) is found to be associated with 5 conditions by eHealthMe. Check the latest studies of Benign positional vertigo.
- Open angle glaucoma (an eye disease that gradually steals vision) is found to be associated with 1,768 drugs and 1,677 conditions by eHealthMe. Check the latest studies of Open angle glaucoma.
- Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development) is found to be associated with 1,617 drugs and 2,600 conditions by eHealthMe. Check the latest studies of Hypothyroidism.
- Depression is found to be associated with 3,167 drugs and 4,129 conditions by eHealthMe. Check the latest studies of Depression.
Comparison with patient's specific adverse outcomes:
You can check what is more associated with an adverse outcome: a drug mix, a drug, a condition, or a population of certain gender and age. Each patient is different. It is not uncommon that the results can be inconclusive or insignificant.
By the same drug(s):
-
Tinnitus (a ringing in the ears):
- among females aged 65 (±5) who take the same drugs: 0.38% (4 of 1,048)
- among people who take the same drugs, regardless of gender or age: 0.06% (4 of 6,707) -
Lumbar Spinal Stenosis (a medical condition in which the spinal canal narrows and compresses the spinal cord and nerves at the level of the lumbar bone):
- among females aged 65 (±5) who take the same drugs: 0% (0 of 1,048)
- among people who take the same drugs, regardless of gender or age: 0% (0 of 6,707) -
Benign Positional Vertigo (disorder arising in the inner ear cause vertigo):
- among females aged 65 (±5) who take the same drugs: 0% (0 of 1,048)
- among people who take the same drugs, regardless of gender or age: 0% (0 of 6,707) -
Open Angle Glaucoma (an eye disease that gradually steals vision):
- among females aged 65 (±5) who take the same drugs: 0% (0 of 1,048)
- among people who take the same drugs, regardless of gender or age: 0% (0 of 6,707) -
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development):
- among females aged 65 (±5) who take the same drugs: 0.19% (2 of 1,048)
- among people who take the same drugs, regardless of gender or age: 0.03% (2 of 6,707) -
Depression:
- among females aged 65 (±5) who take the same drugs: 1.24% (13 of 1,048)
- among people who take the same drugs, regardless of gender or age: 0.19% (13 of 6,707)
By each condition:
-
people who have Benign Positional Vertigo with Menopause:
- among females aged 65 (±5) who have Menopause: 0% (0 of 1,982)
- among people who have Menopause, regardless of gender or age: 0% (0 of 9,747) -
people who have Benign Positional Vertigo with Hypothyroidism:
- among females aged 65 (±5) who have Hypothyroidism: 0% (0 of 19,367)
- among people who have Hypothyroidism, regardless of gender or age: 0% (0 of 114,168) -
people who have Depression with Menopause:
- among females aged 65 (±5) who have Menopause: 5.8% (115 of 1,982)
- among people who have Menopause, regardless of gender or age: 6.19% (603 of 9,747) -
people who have Depression with Hypothyroidism:
- among females aged 65 (±5) who have Hypothyroidism: 2.52% (489 of 19,367)
- among people who have Hypothyroidism, regardless of gender or age: 2.8% (3,194 of 114,168) -
people who have Hypothyroidism with Menopause:
- among females aged 65 (±5) who have Menopause: 0.71% (14 of 1,982)
- among people who have Menopause, regardless of gender or age: 0.6% (58 of 9,747) -
people who have Lumbar Spinal Stenosis with Hypothyroidism:
- among females aged 65 (±5) who have Hypothyroidism: 0.18% (35 of 19,367)
- among people who have Hypothyroidism, regardless of gender or age: 0.1% (113 of 114,168) -
people who have Lumbar Spinal Stenosis with Menopause:
- among females aged 65 (±5) who have Menopause: 0.25% (5 of 1,982)
- among people who have Menopause, regardless of gender or age: 0.32% (31 of 9,747) -
people who have Open Angle Glaucoma with Menopause:
- among females aged 65 (±5) who have Menopause: 0.35% (7 of 1,982)
- among people who have Menopause, regardless of gender or age: 0.28% (27 of 9,747) -
people who have Open Angle Glaucoma with Hypothyroidism:
- among females aged 65 (±5) who have Hypothyroidism: 0.28% (54 of 19,367)
- among people who have Hypothyroidism, regardless of gender or age: 0.21% (236 of 114,168) -
people who have Tinnitus with Hypothyroidism:
- among females aged 65 (±5) who have Hypothyroidism: 0.89% (172 of 19,367)
- among people who have Hypothyroidism, regardless of gender or age: 0.66% (750 of 114,168) -
people who have Tinnitus with Menopause:
- among females aged 65 (±5) who have Menopause: 1.06% (21 of 1,982)
- among people who have Menopause, regardless of gender or age: 1.69% (165 of 9,747)
By each drug (FDA data only):
-
people who take Estradiol and have Benign Positional Vertigo:
- among females aged 65 (±5) who take Estradiol and have side effects: 0% (0 of 2,701)
- among people who take Estradiol and have side effects, regardless of gender or age: 0% (0 of 17,355) -
people who take Cytomel and have Benign Positional Vertigo:
- among females aged 65 (±5) who take Cytomel and have side effects: 0% (0 of 973)
- among people who take Cytomel and have side effects, regardless of gender or age: 0% (0 of 6,807) -
people who take Progesterone and have Benign Positional Vertigo:
- among females aged 65 (±5) who take Progesterone and have side effects: 0% (0 of 2,441)
- among people who take Progesterone and have side effects, regardless of gender or age: 0% (0 of 20,010) -
people who take Estradiol and have Depression:
- among females aged 65 (±5) who take Estradiol and have side effects: 2.26% (61 of 2,701)
- among people who take Estradiol and have side effects, regardless of gender or age: 2.77% (480 of 17,355) -
people who take Cytomel and have Depression:
- among females aged 65 (±5) who take Cytomel and have side effects: 6.37% (62 of 973)
- among people who take Cytomel and have side effects, regardless of gender or age: 5.08% (346 of 6,807) -
people who take Progesterone and have Depression:
- among females aged 65 (±5) who take Progesterone and have side effects: 3.28% (80 of 2,441)
- among people who take Progesterone and have side effects, regardless of gender or age: 2.83% (566 of 20,010) -
people who take Cytomel and have Hypothyroidism:
- among females aged 65 (±5) who take Cytomel and have side effects: 1.64% (16 of 973)
- among people who take Cytomel and have side effects, regardless of gender or age: 2.35% (160 of 6,807) -
people who take Estradiol and have Hypothyroidism:
- among females aged 65 (±5) who take Estradiol and have side effects: 0.19% (5 of 2,701)
- among people who take Estradiol and have side effects, regardless of gender or age: 0.2% (34 of 17,355) -
people who take Progesterone and have Hypothyroidism:
- among females aged 65 (±5) who take Progesterone and have side effects: 0.86% (21 of 2,441)
- among people who take Progesterone and have side effects, regardless of gender or age: 0.64% (128 of 20,010) -
people who take Progesterone and have Lumbar Spinal Stenosis:
- among females aged 65 (±5) who take Progesterone and have side effects: 0.08% (2 of 2,441)
- among people who take Progesterone and have side effects, regardless of gender or age: 0.1% (20 of 20,010) -
people who take Estradiol and have Lumbar Spinal Stenosis:
- among females aged 65 (±5) who take Estradiol and have side effects: 0.04% (1 of 2,701)
- among people who take Estradiol and have side effects, regardless of gender or age: 0.08% (14 of 17,355) -
people who take Cytomel and have Lumbar Spinal Stenosis:
- among females aged 65 (±5) who take Cytomel and have side effects: 1.64% (16 of 973)
- among people who take Cytomel and have side effects, regardless of gender or age: 0.38% (26 of 6,807) -
people who take Cytomel and have Open Angle Glaucoma:
- among females aged 65 (±5) who take Cytomel and have side effects: 1.13% (11 of 973)
- among people who take Cytomel and have side effects, regardless of gender or age: 0.28% (19 of 6,807) -
people who take Progesterone and have Open Angle Glaucoma:
- among females aged 65 (±5) who take Progesterone and have side effects: 0.37% (9 of 2,441)
- among people who take Progesterone and have side effects, regardless of gender or age: 0.08% (17 of 20,010) -
people who take Estradiol and have Open Angle Glaucoma:
- among females aged 65 (±5) who take Estradiol and have side effects: 0.89% (24 of 2,701)
- among people who take Estradiol and have side effects, regardless of gender or age: 0.29% (50 of 17,355) -
people who take Estradiol and have Tinnitus:
- among females aged 65 (±5) who take Estradiol and have side effects: 0.63% (17 of 2,701)
- among people who take Estradiol and have side effects, regardless of gender or age: 0.67% (117 of 17,355) -
people who take Progesterone and have Tinnitus:
- among females aged 65 (±5) who take Progesterone and have side effects: 0.98% (24 of 2,441)
- among people who take Progesterone and have side effects, regardless of gender or age: 0.77% (154 of 20,010) -
people who take Cytomel and have Tinnitus:
- among females aged 65 (±5) who take Cytomel and have side effects: 0.92% (9 of 973)
- among people who take Cytomel and have side effects, regardless of gender or age: 0.63% (43 of 6,807)
Common drug interactions *:
- Nausea (feeling of having an urge to vomit): 88 people, 8.40%
- Fatigue (feeling of tiredness): 88 people, 8.40%
- Headache (pain in head): 82 people, 7.82%
- Drug Ineffective : 73 people, 6.97%
- Stress And Anxiety : 69 people, 6.58%
- Fall : 68 people, 6.49%
- Breast Cancer : 66 people, 6.30%
- Joint Pain : 65 people, 6.20%
- Pain : 63 people, 6.01%
- Dizziness : 61 people, 5.82%
- Diarrhea : 58 people, 5.53%
- High Blood Pressure : 55 people, 5.25%
- Weakness : 54 people, 5.15%
- Pain In Extremity : 52 people, 4.96%
- Insomnia (sleeplessness): 49 people, 4.68%
- Rashes (redness): 46 people, 4.39%
- Malaise (a feeling of general discomfort or uneasiness): 46 people, 4.39%
- Depression : 43 people, 4.10%
- Feeling Abnormal : 39 people, 3.72%
- Dyspnea (difficult or laboured breathing): 38 people, 3.63%
Common co-existing conditions *:
You may use this to check any potential undetected conditions.
- Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 67 people, 6.39%
- High Blood Pressure : 53 people, 5.06%
- Pain : 53 people, 5.06%
- High Blood Cholesterol : 48 people, 4.58%
- Immunodeficiency Common Variable : 47 people, 4.48%
- Hot Flush (sudden feelings of heat): 45 people, 4.29%
- Menopausal Symptoms : 41 people, 3.91%
- Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 41 people, 3.91%
- Depression : 35 people, 3.34%
- Stress And Anxiety : 31 people, 2.96%
- Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 29 people, 2.77%
- Vulvovaginal Dryness : 27 people, 2.58%
- Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 25 people, 2.39%
- Osteoporosis (bones weak and more likely to break): 25 people, 2.39%
- Insomnia (sleeplessness): 24 people, 2.29%
- Sleep Disorder : 24 people, 2.29%
- Migraine (headache): 23 people, 2.19%
- Primary Immunodeficiency Syndrome : 21 people, 2.00%
- Diabetes : 19 people, 1.81%
- Asthma : 18 people, 1.72%
Common co-used drugs *:
You may use this to check any potential interacting drugs.
- Synthroid (162 people, 15.46%)
- Vitamin D3 (118 people, 11.26%)
- Provera (104 people, 9.92%)
- Premarin (98 people, 9.35%)
- Acetaminophen (83 people, 7.92%)
- Prempro (81 people, 7.73%)
- Fish Oil (74 people, 7.06%)
- Vitamin C (72 people, 6.87%)
- Prednisone (66 people, 6.30%)
- Calcium (66 people, 6.30%)
- Xyrem (56 people, 5.34%)
- Magnesium (56 people, 5.34%)
- Epinephrine (55 people, 5.25%)
- Omeprazole (51 people, 4.87%)
- Vitamin D (50 people, 4.77%)
- Aspirin (50 people, 4.77%)
- Folic Acid (49 people, 4.68%)
- Zyrtec (49 people, 4.68%)
- Biotin (47 people, 4.48%)
- Coenzyme Q10 (47 people, 4.48%)
Drug effectiveness *:
Cytomel:
- not at all: 0 %
- somewhat: 0 %
- moderate: 50 %
- high: 25 %
- very high: 25 %
Estradiol:
- not at all: 0 %
- somewhat: 12.5 %
- moderate: 25.0 %
- high: 25.0 %
- very high: 37.5 %
Progesterone:
- not at all: 0 %
- somewhat: 14.29 %
- moderate: 28.57 %
- high: 42.86 %
- very high: 14.29 %
* Some reports may have incomplete information.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Related studies
Drug side effects in long term, by gender and age:
- Cytomel: 7,595 reports
- Estradiol: 18,986 reports
- Progesterone: 21,021 reports
Treatments, associated medications and conditions:
- Benign positional vertigo: 70 reports
- Depression: 652,152 reports
- Hypothyroidism: 168,067 reports
- Lumbar spinal stenosis: 6,965 reports
- Menopause: 14,552 reports
- Open angle glaucoma: 61,927 reports
- Tinnitus: 58,552 reports
Drug side effects:
- Cytomel and Tinnitus (43 reports)
- Estradiol and Tinnitus (117 reports)
- Progesterone and Tinnitus (154 reports)
- Cytomel and Lumbar spinal stenosis (26 reports)
- Estradiol and Lumbar spinal stenosis (14 reports)
- Progesterone and Lumbar spinal stenosis (20 reports)
- Cytomel and Benign positional vertigo
- Estradiol and Benign positional vertigo
- Progesterone and Benign positional vertigo
- Cytomel and Open angle glaucoma (20 reports)
- Estradiol and Open angle glaucoma (50 reports)
- Progesterone and Open angle glaucoma (18 reports)
- Cytomel and Hypothyroidism (160 reports)
- Estradiol and Hypothyroidism (34 reports)
- Progesterone and Hypothyroidism (128 reports)
- Cytomel and Depression (346 reports)
- Estradiol and Depression (480 reports)
- Progesterone and Depression (566 reports)
Drug interactions:
- Cytomel and Estradiol drug interaction (72 reports)
- Cytomel and Progesterone drug interaction (244 reports)
- Estradiol and Progesterone drug interaction (1,802 reports)
Symptoms:
- Hypothyroidism and Tinnitus (750 reports)
- Hypothyroidism and Lumbar spinal stenosis (113 reports)
- Hypothyroidism and Benign positional vertigo
- Hypothyroidism and Open angle glaucoma (236 reports)
- Hypothyroidism and Hypothyroidism (1,680 reports)
- Hypothyroidism and Depression (3,194 reports)
- Menopause and Tinnitus (165 reports)
- Menopause and Lumbar spinal stenosis (31 reports)
- Menopause and Benign positional vertigo
- Menopause and Open angle glaucoma (27 reports)
- Menopause and Hypothyroidism (58 reports)
- Menopause and Depression (603 reports)
Drugs that are associated with:
- Tinnitus: 1,668 drugs
- Lumbar spinal stenosis: 765 drugs
- Benign positional vertigo: 0 drugs
- Open angle glaucoma: 1,768 drugs
- Hypothyroidism: 1,617 drugs
- Depression: 3,167 drugs
Conditions that are associated with:
- Tinnitus: 3,065 conditions
- Lumbar spinal stenosis: 694 conditions
- Benign positional vertigo: 5 conditions
- Open angle glaucoma: 1,677 conditions
- Hypothyroidism: 2,600 conditions
- Depression: 4,129 conditions
How the phase IV clinical study uses the data?
The study is based on gender, age, active ingredients of any drugs used. Other drugs that have the same active ingredients (e.g. generic drugs) are considered. Dosage of drugs is not considered in the study.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
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