Benadryl side effects, by duration, gender and age (a phase IV clinical study of FDA data)
Summary:
Side effects are reported by people who take Benadryl (diphenhydramine hydrochloride). Common side effects include abdominal pain among females and death among males.
The phase IV clinical study is created by eHealthMe based on 100,253 reports from the FDA, and is updated regularly.
What is Benadryl?
Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,954 Benadryl users. Check the latest studies of Benadryl.
100,253 people who take Benadryl and have side effects are studied.

What are the common side effects of Benadryl, by gender? *
What are the common side effects of Benadryl, by age (0-1 to 60+)? *
What are the common side effects of Benadryl, by the time people have been on the drug (< 1 month to 10+ years)? *
* Approximation only. Some reports may have incomplete information.
Do you take Benadryl?
- Personalize this study to your gender and age- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
How the study uses the data?
The study is based on diphenhydramine hydrochloride (the active ingredients of Benadryl) and Benadryl (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered.
Related studies are listed below in case you need more information:
Alternative drugs to, pros and cons of Benadryl:
- Benadryl (104,954 reports)
All Benadryl side effects from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zWho is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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