Folex side effects, by duration, gender and age (a phase IV clinical study of FDA data)

female:

1. Febrile bone marrow aplasia (bone marrow greatly decreases or stops production of blood cells)
2. Abdominal pain
3. Balance disorder
4. Blood pressure increased
5. Bradycardia (abnormally slow heart action)
6. Cough
7. Myalgia (muscle pain)
8. Abdominal discomfort
9. Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
10. Asthenia (weakness)

male:

1. Diarrhoea
2. Cardiac failure
3. Fall
4. Feeling hot
5. Flushing (the warm, red condition of human skin)
6. Injection site irritation
7. International normalised ratio decreased
8. Interstitial lung disease
9. Neutropenia (an abnormally low number of neutrophils)
10. Pneumonia

0-1:

n/a

2-9:

n/a

10-19:

1. Febrile bone marrow aplasia (bone marrow greatly decreases or stops production of blood cells)

20-29:

n/a

30-39:

1. Rhinorrhoea (watery mucus discharge from the nose)

40-49:

1. Pneumonia

50-59:

1. Diarrhoea
2. Balance disorder
3. Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
4. Ageusia (loss of taste functions of the tongue)
5. Back pain
6. Flushing (the warm, red condition of human skin)

60+:

1. Cough
2. Empyema (collection of pus in a cavity in the body)
3. Myalgia (muscle pain)
4. Abdominal discomfort
5. Abdominal pain
6. Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
7. Blood cholesterol increased
8. Breast oedema (build-up of fluid in the breast tissue)
9. Cardiac failure congestive
10. Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)

< 1 month:

1. Diarrhoea
2. Asthenia (weakness)

1 - 6 months:

n/a

6 - 12 months:

1. Cardiac failure congestive

1 - 2 years:

1. Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)

2 - 5 years:

n/a

5 - 10 years:

n/a

10+ years:

n/a

not specified:

1. Blood pressure increased
2. Bradycardia (abnormally slow heart action)
3. Cardiac failure congestive
4. Cough
5. Empyema (collection of pus in a cavity in the body)
6. Myalgia (muscle pain)
7. Abdominal discomfort
8. Ageusia (loss of taste functions of the tongue)
9. Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
10. Anaemia (lack of blood)