Klaron side effects, by duration, gender and age (a phase IV clinical study of FDA data)

female:

1. Drug ineffective
2. Acne (skin problems that cause pimples)
3. Anxiety
4. Cardiac disorder
5. Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
6. Erythema (redness of the skin)
7. Fall
8. Alopecia (absence of hair from areas of the body)
9. Anaemia (lack of blood)
10. Anal pruritus (anal itching)

male:

1. Abdominal pain
2. Acne (skin problems that cause pimples)
3. Candidiasis (candidiasis or thrush is a fungal infection)
4. Epiphyses premature fusion
5. Haemorrhage intracranial (bleeding within the skull)
6. Lip discolouration
7. Lymphoma (cancer that begins in immune system cells)
8. Skin discolouration (change of skin colour)

0-1:

n/a

2-9:

n/a

10-19:

1. Abdominal pain
2. Acne (skin problems that cause pimples)
3. Epiphyses premature fusion
4. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
5. Discomfort
6. Pulmonary embolism (blockage of the main artery of the lung)
7. Rash erythematous (redness of the skin)
8. Skin discolouration (change of skin colour)

20-29:

1. Intracranial pressure increased (high pressure inside the skull and thus in the brain tissue and cerebrospinal fluid)
2. Lip discolouration
3. Metrorrhagia (uterine bleeding at irregular intervals)

30-39:

1. Anxiety
2. Drug ineffective
3. Erythema (redness of the skin)
4. Flushing (the warm, red condition of human skin)

40-49:

1. Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
2. Abdominal discomfort
3. Abdominal pain
4. Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
5. Drug ineffective
6. Erythema (redness of the skin)
7. Injection site nodule (small swelling or aggregation of cells in the body, esp. an abnormal one at injection site)
8. Malaise (a feeling of general discomfort or uneasiness)

50-59:

1. Candidiasis (candidiasis or thrush is a fungal infection)
2. Acne (skin problems that cause pimples)
3. Alopecia (absence of hair from areas of the body)
4. Dry mouth
5. Dyspepsia (indigestion)
6. Lymphoma (cancer that begins in immune system cells)
7. Pleural effusion (water on the lungs)

60+:

1. Abdominal pain
2. Cardiac disorder
3. Fall
4. Acne (skin problems that cause pimples)
5. Anaemia (lack of blood)
6. Anal pruritus (anal itching)
7. Blood creatinine increased
8. Contrast media allergy (reaction associated with the use of intravenous contrast material during radiology)
9. Dry skin
10. Haemorrhage intracranial (bleeding within the skull)

< 1 month:

n/a

1 - 6 months:

n/a

6 - 12 months:

n/a

1 - 2 years:

n/a

2 - 5 years:

n/a

5 - 10 years:

n/a

10+ years:

1. Burning sensation

not specified:

1. Abdominal pain
2. Erythema (redness of the skin)
3. Fall
4. Alopecia (absence of hair from areas of the body)
5. Anaemia (lack of blood)
6. Anal pruritus (anal itching)
7. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
8. Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
9. Blood creatinine increased
10. Cholecystitis (infection of gallbladder)