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Ortho cyclen-21 side effects, by duration, gender and age (a phase IV clinical study of FDA data)

Summary:

Side effects are reported by people who take Ortho cyclen-21 (ethinyl estradiol; norgestimate). Common side effects include drug exposure during pregnancy among females.

The phase IV clinical study is created by eHealthMe based on 100 reports from the FDA, and is updated regularly.

What is Ortho Cyclen-21?

Ortho cyclen-21 has active ingredients of ethinyl estradiol; norgestimate. It is often used in birth control. eHealthMe is studying from 174 Ortho cyclen-21 users. Check the latest studies of Ortho cyclen-21.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.



On Sep, 01, 2026

100 people who take Ortho Cyclen-21 and have side effects are studied.

Ortho cyclen-21 side effects.

What are the common side effects of Ortho Cyclen-21, by gender? *:

female:

  1. Drug exposure during pregnancy
  2. Abdominal pain
  3. Accidental exposure
  4. Affect lability (emotional incontinence)
  5. Affective disorder (mental disorder)
  6. Alopecia (absence of hair from areas of the body)
  7. Anaemia (lack of blood)
  8. Angle closure glaucoma (term used for several ocular diseases that ultimately result in increased intraocular pressure (iop) and decreased visual acuity)
  9. Aphasia (damage to the parts of the brain that control language)
  10. Atrioventricular block second degree (heart block second degree)

male:

n/a

What are the common side effects of Ortho Cyclen-21, by age (0-1 to 60+) *:

0-1:

n/a

2-9:

n/a

10-19:

  1. Nausea (feeling of having an urge to vomit)
  2. Pelvic venous thrombosis (blood clot occurring inside a blood vessel and thromboses (dvts) that form in the deep veins of the legs or in the pelvic veins)

20-29:

  1. Adjustment disorder
  2. Abdominal pain
  3. Colitis ulcerative (inflammation of colon with ulcer)
  4. Drug exposure during pregnancy
  5. Abortion spontaneous (naturally occurring miscarriage)
  6. Affect lability (emotional incontinence)
  7. Affective disorder (mental disorder)
  8. Alopecia (absence of hair from areas of the body)
  9. Anaemia (lack of blood)
  10. Angle closure glaucoma (term used for several ocular diseases that ultimately result in increased intraocular pressure (iop) and decreased visual acuity)

30-39:

  1. Accident
  2. Acne (skin problems that cause pimples)
  3. Confusional state
  4. Constipation
  5. Cough
  6. Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
  7. Dermatitis bullous (inflammation of the skin characterized by the presence of bullae which are filled with fluid)
  8. Flatulence (flatus expelled through the anus)
  9. Hypertrichosis (hair growth on the body in an amount considered abnormal)
  10. Oedema peripheral (superficial swelling)

40-49:

  1. Asthma
  2. Abdominal pain
  3. Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)
  4. Menstruation delayed (late menstruation cycle)
  5. Pulmonary embolism (blockage of the main artery of the lung)

50-59:

n/a

60+:

n/a

What are the common side effects of Ortho Cyclen-21, by the time people have been on the drug (< 1 month to 10+ years)? *:

< 1 month:

n/a

1 - 6 months:

  1. Aphasia (damage to the parts of the brain that control language)

6 - 12 months:

n/a

1 - 2 years:

n/a

2 - 5 years:

n/a

5 - 10 years:

n/a

10+ years:

n/a

not specified:

  1. Drug exposure during pregnancy
  2. Abortion spontaneous (naturally occurring miscarriage)
  3. Accident
  4. Accidental exposure
  5. Affect lability (emotional incontinence)
  6. Affective disorder (mental disorder)
  7. Alopecia (absence of hair from areas of the body)
  8. Anaemia (lack of blood)
  9. Angle closure glaucoma (term used for several ocular diseases that ultimately result in increased intraocular pressure (iop) and decreased visual acuity)
  10. Atrioventricular block second degree (heart block second degree)

* Approximation only. Some reports may have incomplete information.

Do you take Ortho cyclen-21?

- Personalize this study to your gender and age
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.



How the study uses the data?

The study is based on ethinyl estradiol; norgestimate (the active ingredients of Ortho cyclen-21) and Ortho cyclen-21 (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered.

Related studies are listed below in case you need more information:

Alternative drugs to, pros and cons of Ortho cyclen-21:

All Ortho cyclen-21 side effects from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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