Ortho-est side effects, by duration, gender and age (a phase IV clinical study of FDA data)

Summary:

Side effects are reported by people who take Ortho-est (estropipate). Common side effects include convulsion among females and abdominal hernia among males.

The phase IV clinical study is created by eHealthMe based on 49 reports from the FDA, and is updated regularly.

What is Ortho-Est?

Ortho-est has active ingredients of estropipate. eHealthMe is studying from 52 Ortho-est users. Check the latest studies of Ortho-est.



On Jul, 23, 2026

49 people who take Ortho-Est and have side effects are studied.

Ortho-est side effects.

What are the common side effects of Ortho-Est, by gender? *:

female:

  1. Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
  2. Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
  3. Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
  4. Abdominal pain
  5. Difficulty in walking
  6. Epistaxis (bleed from the nose)
  7. Fall
  8. Hypertonia (abnormal increase in muscle tension and a reduced ability of a muscle to stretch)
  9. Weight increased
  10. Breast cancer

male:

  1. Abdominal hernia
  2. Anxiety
  3. Breast cancer female

What are the common side effects of Ortho-Est, by age (0-1 to 60+) *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
  2. Breast cancer female

40-49:

  1. Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
  2. Abdominal hernia
  3. Weight increased

50-59:

  1. Breast cancer
  2. Diarrhoea
  3. Abdominal distension
  4. Agitation (state of anxiety or nervous excitement)
  5. Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
  6. Anxiety
  7. Breast cancer female

60+:

  1. Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
  2. Arthralgia (joint pain)
  3. Breast cancer
  4. Breast cancer female
  5. Difficulty in walking
  6. Epistaxis (bleed from the nose)
  7. Fall
  8. Hypertonia (abnormal increase in muscle tension and a reduced ability of a muscle to stretch)

What are the common side effects of Ortho-Est, by the time people have been on the drug (< 1 month to 10+ years)? *:

< 1 month:

n/a

1 - 6 months:

n/a

6 - 12 months:

n/a

1 - 2 years:

  1. Abdominal hernia

2 - 5 years:

  1. Breast cancer female

5 - 10 years:

  1. Breast cancer female

10+ years:

n/a

not specified:

  1. Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
  2. Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
  3. Abdominal pain
  4. Anxiety
  5. Difficulty in walking
  6. Epistaxis (bleed from the nose)
  7. Fall
  8. Hypertonia (abnormal increase in muscle tension and a reduced ability of a muscle to stretch)
  9. Weight increased
  10. Breast cancer

* Approximation only. Some reports may have incomplete information.

Do you take Ortho-est?

- Personalize this study to your gender and age
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.



How the study uses the data?

The study is based on estropipate (the active ingredients of Ortho-est) and Ortho-est (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered.

Related studies are listed below in case you need more information:

Alternative drugs to, pros and cons of Ortho-est:

All Ortho-est side effects from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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