Principen side effects, by duration, gender and age (a phase IV clinical study of FDA data)

female:

1. Acute myocardial infarction (acute heart attack)
2. Anaemia (lack of blood)
3. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
4. Abdominal discomfort
5. Abdominal pain
6. Acute sinusitis
7. Alopecia (absence of hair from areas of the body)
8. Aortic valve incompetence
9. Chest pain
10. Chickenpox (infection with varicella zoster virus)

male:

1. Abdominal pain
2. Arthralgia (joint pain)
3. Plasma cell myeloma (cancer that begins in plasma cells)
4. Pneumonia
5. Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
6. Blood pressure abnormal
7. Colitis ulcerative (inflammation of colon with ulcer)
8. Asthenia (weakness)
9. Bile duct stenosis (abnormal narrowing of the common bile duct)
10. Dehydration (dryness resulting from the removal of water)

0-1:

n/a

2-9:

n/a

10-19:

1. Abdominal pain
2. Arthralgia (joint pain)
3. Colitis ulcerative (inflammation of colon with ulcer)
4. Mouth ulceration (mouth ulcers)
5. Protein urine
6. Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)

20-29:

1. Colitis ulcerative (inflammation of colon with ulcer)

30-39:

1. Chills (felling of cold)
2. Epidermal necrolysis (skin condition that is usually caused by a reaction to drugs)
3. Hypersensitivity

40-49:

1. Drug hypersensitivity
2. Anaemia (lack of blood)
3. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
4. Chickenpox (infection with varicella zoster virus)
5. Plasma cell myeloma (cancer that begins in plasma cells)

50-59:

1. Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
2. Acute sinusitis
3. Chest pain

60+:

1. Anaemia (lack of blood)
2. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
3. Blood pressure abnormal
4. Abdominal discomfort
5. Alopecia (absence of hair from areas of the body)
6. Asthenia (weakness)
7. Bile duct stenosis (abnormal narrowing of the common bile duct)
8. Confusion
9. Haemorrhage subepidermal (bleeding from the skin)
10. Pneumonia

< 1 month:

1. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
2. Chills (felling of cold)
3. Hypersensitivity

1 - 6 months:

n/a

6 - 12 months:

n/a

1 - 2 years:

n/a

2 - 5 years:

n/a

5 - 10 years:

n/a

10+ years:

n/a

not specified:

1. Colitis ulcerative (inflammation of colon with ulcer)
2. Abdominal discomfort
3. Acute sinusitis
4. Alopecia (absence of hair from areas of the body)
5. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
6. Ankle fracture
7. Aortic valve incompetence
8. Asthenia (weakness)
9. Bile duct stenosis (abnormal narrowing of the common bile duct)
10. Chest pain