Simpesse side effects, by duration, gender and age (a phase IV clinical study of FDA data)

Summary:

Side effects are reported by people who take Simpesse (ethinyl estradiol; levonorgestrel). Common side effects include diarrhoea among females.

The phase IV clinical study is created by eHealthMe based on 33 reports from the FDA, and is updated regularly.

What is Simpesse?

Simpesse has active ingredients of ethinyl estradiol; levonorgestrel. It is often used in birth control. eHealthMe is studying from 40 Simpesse users. Check the latest studies of Simpesse.



On Aug, 11, 2026

33 people who take Simpesse and have side effects are studied.

Simpesse side effects.

What are the common side effects of Simpesse, by gender? *:

female:

  1. Diarrhoea
  2. Acne (skin problems that cause pimples)
  3. Nausea (feeling of having an urge to vomit)
  4. Pain
  5. Post procedural complication
  6. Pulmonary embolism (blockage of the main artery of the lung)
  7. Sinusitis (inflammation of sinus)
  8. White blood cell count decreased
  9. Alopecia (absence of hair from areas of the body)
  10. Asthma

male:

n/a

What are the common side effects of Simpesse, by age (0-1 to 60+) *:

0-1:

n/a

2-9:

n/a

10-19:

  1. Discomfort
  2. Pain
  3. White blood cell count decreased

20-29:

  1. Acne (skin problems that cause pimples)
  2. Alopecia (absence of hair from areas of the body)
  3. Asthma
  4. Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
  5. Sinusitis (inflammation of sinus)

30-39:

  1. Acne (skin problems that cause pimples)
  2. Pulmonary embolism (blockage of the main artery of the lung)

40-49:

  1. Post procedural complication
  2. Diarrhoea
  3. Alopecia (absence of hair from areas of the body)
  4. Asthma
  5. Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)

50-59:

n/a

60+:

n/a

What are the common side effects of Simpesse, by the time people have been on the drug (< 1 month to 10+ years)? *:

< 1 month:

  1. Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)

1 - 6 months:

n/a

6 - 12 months:

n/a

1 - 2 years:

n/a

2 - 5 years:

n/a

5 - 10 years:

n/a

10+ years:

n/a

not specified:

  1. Diarrhoea
  2. Nausea (feeling of having an urge to vomit)
  3. Pain
  4. Post procedural complication
  5. Pulmonary embolism (blockage of the main artery of the lung)
  6. Sinusitis (inflammation of sinus)
  7. White blood cell count decreased
  8. Acne (skin problems that cause pimples)
  9. Alopecia (absence of hair from areas of the body)
  10. Asthma

* Approximation only. Some reports may have incomplete information.

Do you take Simpesse?

- Personalize this study to your gender and age
- Predict drug outcomes for up to one year with AI
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How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.



How the study uses the data?

The study is based on ethinyl estradiol; levonorgestrel (the active ingredients of Simpesse) and Simpesse (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered.

Related studies are listed below in case you need more information:

Alternative drugs to, pros and cons of Simpesse:

All Simpesse side effects from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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