Zantac 300 side effects, by duration, gender and age (a phase IV clinical study of FDA data)

Summary:

Side effects are reported by people who take Zantac 300 (ranitidine hydrochloride). Common side effects include chronic kidney disease among females and chronic kidney disease among males.

The phase IV clinical study is created by eHealthMe based on 90 reports from the FDA, and is updated regularly.

What is Zantac 300?

Zantac 300 has active ingredients of ranitidine hydrochloride. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 283 Zantac 300 users. Check the latest studies of Zantac 300.



On Jul, 08, 2026

90 people who take Zantac 300 and have side effects are studied.

Zantac 300 side effects.

What are the common side effects of Zantac 300, by gender? *:

female:

  1. Chronic kidney disease
  2. Abnormal behaviour
  3. Arthralgia (joint pain)
  4. Confusion
  5. Depression
  6. Dermatitis bullous (inflammation of the skin characterized by the presence of bullae which are filled with fluid)
  7. Drug ineffective
  8. Eructation (release of gas from the digestive tract)
  9. Mouth ulceration (mouth ulcers)
  10. Neutropenia (an abnormally low number of neutrophils)

male:

  1. Chronic kidney disease
  2. Depression aggravated
  3. Cerebral ventricle dilatation (enlargement of ventricle of brain)
  4. Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
  5. Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
  6. Cough
  7. Henoch-schonlein purpura (inflammation of the blood vessels in the skin and other body organs)
  8. International normalised ratio increased
  9. Stevens johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
  10. Epidermal necrolysis (skin condition that is usually caused by a reaction to drugs)

What are the common side effects of Zantac 300, by age (0-1 to 60+) *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Epidermal necrolysis (skin condition that is usually caused by a reaction to drugs)
  2. Eructation (release of gas from the digestive tract)

40-49:

  1. Chronic kidney disease
  2. Abnormal behaviour
  3. Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
  4. Blood bilirubin increased
  5. Cough
  6. International normalised ratio increased

50-59:

  1. Chronic kidney disease
  2. Angina unstable (chest pain due to ischemia of the heart muscle- unstable)
  3. Arthralgia (joint pain)
  4. Bipolar ii disorder (characterized by at least one episode of hypomania and at least one episode of major depression)
  5. Cerebral ventricle dilatation (enlargement of ventricle of brain)
  6. Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
  7. Mouth ulceration (mouth ulcers)
  8. Neutropenia (an abnormally low number of neutrophils)

60+:

  1. Dermatitis bullous (inflammation of the skin characterized by the presence of bullae which are filled with fluid)
  2. Epidermal necrolysis (skin condition that is usually caused by a reaction to drugs)
  3. Henoch-schonlein purpura (inflammation of the blood vessels in the skin and other body organs)
  4. Palpitations (feelings or sensations that your heart is pounding or racing)
  5. Stevens johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
  6. Chronic kidney disease
  7. Depression aggravated
  8. Acute hepatic failure
  9. C-reactive protein increased
  10. Cholestasis (a condition where bile cannot flow from the liver to the duodenum)

What are the common side effects of Zantac 300, by the time people have been on the drug (< 1 month to 10+ years)? *:

< 1 month:

n/a

1 - 6 months:

  1. Henoch-schonlein purpura (inflammation of the blood vessels in the skin and other body organs)

6 - 12 months:

  1. Chronic kidney disease

1 - 2 years:

n/a

2 - 5 years:

  1. Chronic kidney disease

5 - 10 years:

  1. Chronic kidney disease

10+ years:

n/a

not specified:

  1. Angina unstable (chest pain due to ischemia of the heart muscle- unstable)
  2. Arthralgia (joint pain)
  3. Bipolar ii disorder (characterized by at least one episode of hypomania and at least one episode of major depression)
  4. Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
  5. Blood bilirubin increased
  6. C-reactive protein increased
  7. Cerebral ventricle dilatation (enlargement of ventricle of brain)
  8. Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
  9. Confusion
  10. Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)

* Approximation only. Some reports may have incomplete information.

Do you take Zantac 300?

- Personalize this study to your gender and age
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.



How the study uses the data?

The study is based on ranitidine hydrochloride (the active ingredients of Zantac 300) and Zantac 300 (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered.

Related studies are listed below in case you need more information:

Alternative drugs to, pros and cons of Zantac 300:

All Zantac 300 side effects from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



Recent studies on eHealthMe: