Accolate and Extremity necrosis - a phase IV clinical study of FDA data

Summary:

Extremity necrosis is reported as a side effect among people who take Accolate (zafirlukast), especially for people who are female, 60+ old, also take Lipitor, and have Sinusitis.

The phase IV clinical study analyzes which people have Extremity necrosis when taking Accolate. It is created by eHealthMe based on reports of 4,145 people who have side effects when taking Accolate from the FDA, and is updated regularly.

What is Accolate?

Accolate has active ingredients of zafirlukast. It is often used in asthma. eHealthMe is studying from 4,220 Accolate users. Check the latest studies of Accolate.

What is Extremity necrosis?

Extremity necrosis (death of body tissue of arms and legs) is found to be associated with 298 drugs and 411 conditions by eHealthMe. Check the latest studies of Extremity necrosis.

On Aug, 06, 2026

4,145 people reported to have side effects when taking Accolate.
Among them, 12 people (0.29%) have Extremity necrosis.

Could Accolate cause Extremity necrosis?

Among these 12 people:

What is the gender of people who have Extremity necrosis when taking Accolate? *

female: 100 %
male: 0.0 %

What is the age of people who have Extremity necrosis when taking Accolate? *

What are other drugs people take besides Accolate? *

What are other side effects people have besides Extremity necrosis? *

White Blood Cell Count Increased: 12 people, 100.00%
Sepsis (a severe blood infection that can lead to organ failure and death): 12 people, 100.00%
Abdominal Tenderness: 12 people, 100.00%
Atrial Thrombosis (blood clot that develops in an artery): 12 people, 100.00%
Depression: 12 people, 100.00%
Gastrointestinal Necrosis (destruction of gastrointestinal organ): 12 people, 100.00%
Hypotension (abnormally low blood pressure): 12 people, 100.00%
Impaired Healing: 12 people, 100.00%
Weight Decreased: 12 people, 100.00%
Pseudomembranous Colitis (antibiotic-associated diarrhoea (aad), is an infection of the colon): 12 people, 100.00%

What are the existing conditions these people have? *

Sinusitis (inflammation of sinus): 12 people, 100.00%
Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin): 10 people, 83.33%
Hypotension (abnormally low blood pressure): 10 people, 83.33%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 10 people, 83.33%
Cough: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Accolate and have Extremity necrosis?

- Check whether Extremity necrosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Accolate:

Accolate (4,220 reports)

Browse all side effects of Accolate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Extremity necrosis:

Extremity necrosis (298 drugs)

Browse all the conditions that are associated with Extremity necrosis:

Extremity necrosis (411 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on zafirlukast (the active ingredients of Accolate) and Accolate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.