Acetylcysteine and Splenomegaly - a phase IV clinical study of FDA data

Summary:

Splenomegaly is reported as a side effect among people who take Acetylcysteine (acetylcysteine), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Advair Hfa, and have Productive cough.

The phase IV clinical study analyzes which people have Splenomegaly when taking Acetylcysteine. It is created by eHealthMe based on reports of 11,475 people who have side effects when taking Acetylcysteine from the FDA, and is updated regularly.

What is Acetylcysteine?

Acetylcysteine has active ingredients of acetylcysteine. It is often used in cough. eHealthMe is studying from 11,563 Acetylcysteine users. Check the latest studies of Acetylcysteine.

What is Splenomegaly?

Splenomegaly (enlargement of spleen) is found to be associated with 1,121 drugs and 1,477 conditions by eHealthMe. Check the latest studies of Splenomegaly.

On Jul, 13, 2026

11,475 people reported to have side effects when taking Acetylcysteine.
Among them, 16 people (0.14%) have Splenomegaly.

Could Acetylcysteine cause Splenomegaly?

Among these 16 people:

How long have people been on Acetylcysteine when they have Splenomegaly? *

What is the gender of people who have Splenomegaly when taking Acetylcysteine? *

female: 30.77 %
male: 69.23 %

What is the age of people who have Splenomegaly when taking Acetylcysteine? *

What are other drugs people take besides Acetylcysteine? *

What are other side effects people have besides Splenomegaly? *

Nasopharyngitis (inflammation of the nasopharynx): 6 people, 37.50%
Fever: 6 people, 37.50%
Oxygen Saturation Decreased: 5 people, 31.25%
Idiopathic Pulmonary Fibrosis (chronic lung disease): 5 people, 31.25%
Infusion Related Reaction: 5 people, 31.25%
Dyspnea (difficult or laboured breathing): 5 people, 31.25%
Gastric Haemorrhage (bleeding stomach): 5 people, 31.25%
Lung Infection: 5 people, 31.25%
Heart Rate Irregular: 5 people, 31.25%
Lower Respiratory Tract Infection: 5 people, 31.25%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 5 people, 31.25%
Productive Cough: 5 people, 31.25%
Primary Myelofibrosis (primary disorder of the bone marrow): 3 people, 18.75%
High Blood Pressure: 3 people, 18.75%
Gout (uric acid crystals building up in the body): 3 people, 18.75%
Cardiac Failure: 3 people, 18.75%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 3 people, 18.75%
Upper Respiratory Tract Infection: 1 person, 6.25%
Stress And Anxiety: 1 person, 6.25%
Accelerated Phase Chronic Myologenic Leukaemia (accelerated phase cancer of blood-forming cells in the bone marrow): 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Acetylcysteine and have Splenomegaly?

- Check whether Splenomegaly is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Acetylcysteine:

Acetylcysteine (11,563 reports)

Splenomegaly treatments and more:

Splenomegaly (17,257 reports)

Browse all side effects of Acetylcysteine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Splenomegaly:

Splenomegaly (1,121 drugs)

Browse all the conditions that are associated with Splenomegaly:

Splenomegaly (1,477 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on acetylcysteine (the active ingredients of Acetylcysteine) and Acetylcysteine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.