Acidophilus and Joint stiffness - a phase IV clinical study of FDA data

Summary:

Joint stiffness is reported as a side effect among people who take Acidophilus (lactobacillus), especially for people who are female, 60+ old, also take Vitamin C, and have Urinary tract infection.

The phase IV clinical study analyzes which people have Joint stiffness when taking Acidophilus. It is created by eHealthMe based on reports of 8,205 people who have side effects when taking Acidophilus from the FDA, and is updated regularly.

What is Acidophilus?

Acidophilus has active ingredients of lactobacillus. It is often used in digestive. eHealthMe is studying from 8,440 Acidophilus users. Check the latest studies of Acidophilus.

What is Joint stiffness?

Joint stiffness is found to be associated with 1,300 drugs and 1,340 conditions by eHealthMe. Check the latest studies of Joint stiffness.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 23, 2026

8,205 people reported to have side effects when taking Acidophilus.
Among them, 21 people (0.26%) have Joint stiffness.

Could Acidophilus cause Joint stiffness?

Among these 21 people:

What is the gender of people who have Joint stiffness when taking Acidophilus? *

female: 85.71 %
male: 14.29 %

What is the age of people who have Joint stiffness when taking Acidophilus? *

What are other drugs people take besides Acidophilus? *

What are other side effects people have besides Joint stiffness? *

Diarrhea: 13 people, 61.90%
Joint Pain: 12 people, 57.14%
Stress And Anxiety: 11 people, 52.38%
Hyperhidrosis (abnormally increased sweating): 9 people, 42.86%
Joint Swelling: 9 people, 42.86%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 9 people, 42.86%
Insomnia (sleeplessness): 8 people, 38.10%
Panic Disorder: 7 people, 33.33%
Joint Crepitation: 7 people, 33.33%
Heart Palpitations (feelings or sensations that your heart is pounding or racing): 7 people, 33.33%

What are the existing conditions these people have? *

Urinary Tract Infection: 7 people, 33.33%
Histiocytosis (a blood disease characterized by an abnormal multiplication of macrophages): 4 people, 19.05%
Thrombocytopenia (decrease of platelets in blood): 4 people, 19.05%
Purpura (purplish discoloration of the skin): 4 people, 19.05%
Malaise (a feeling of general discomfort or uneasiness): 2 people, 9.52%
Gastrointestinal Disorder (functional problems of gastrointestinal tract): 2 people, 9.52%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 9.52%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 9.52%
Fever: 2 people, 9.52%
Neoplasm Malignant (cancer tumour): 2 people, 9.52%

* Approximation only. Some reports may have incomplete information.

Do you take Acidophilus and have Joint stiffness?

- Check whether Joint stiffness is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Acidophilus:

Acidophilus (8,440 reports)

Joint stiffness treatments and more:

Joint stiffness (33,165 reports)

Browse all side effects of Acidophilus:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Joint stiffness:

Joint stiffness (1,300 drugs)

Browse all the conditions that are associated with Joint stiffness:

Joint stiffness (1,340 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on lactobacillus (the active ingredients of Acidophilus) and Acidophilus (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.