Aciphex and Hypercoagulation - a phase IV clinical study of FDA data

Summary:

Hypercoagulation is reported as a side effect among people who take Aciphex (rabeprazole sodium), especially for people who are female, 40-49 old, also take Ibuprofen, and have Ovarian cysts.

The phase IV clinical study analyzes which people have Hypercoagulation when taking Aciphex. It is created by eHealthMe based on reports of 24,594 people who have side effects when taking Aciphex from the FDA, and is updated regularly.

What is Aciphex?

Aciphex has active ingredients of rabeprazole sodium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 25,301 Aciphex users. Check the latest studies of Aciphex.

What is Hypercoagulation?

Hypercoagulation (increased tendency for clotting of the blood) is found to be associated with 428 drugs and 533 conditions by eHealthMe. Check the latest studies of Hypercoagulation.

On Dec, 26, 2025

24,594 people reported to have side effects when taking Aciphex.
Among them, 12 people (0.05%) have Hypercoagulation.

Among these 12 people:

What is the gender of people who have Hypercoagulation when taking Aciphex? *

female: 75 %
male: 25 %

What is the age of people who have Hypercoagulation when taking Aciphex? *

What are other drugs people take besides Aciphex? *

What are other side effects people have besides Hypercoagulation? *

Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 8 people, 66.67%
Dizziness: 5 people, 41.67%
Consciousness - Decreased: 5 people, 41.67%
Sinusitis (inflammation of sinus): 5 people, 41.67%
Headache (pain in head): 5 people, 41.67%
Superior Sagittal Sinus Thrombosis (blood clot in the dural venous sinuses, which drain blood from the brain): 5 people, 41.67%
High Blood Pressure: 5 people, 41.67%
Respiratory Acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 5 people, 41.67%
Iron Deficiency Anaemia: 5 people, 41.67%
Protein S Deficiency: 5 people, 41.67%

What are the existing conditions these people have? *

Ovarian Cysts (fluid filled sacs of the ovary): 4 people, 33.33%
Weight Loss: 1 person, 8.33%
Pulmonary Embolism (blockage of the main artery of the lung): 1 person, 8.33%
Polycystic Ovary Disease (cysts in the ovaries that occurs when the follicle stops developing): 1 person, 8.33%
Pain: 1 person, 8.33%
Menstruation Irregular: 1 person, 8.33%
Joint Pain: 1 person, 8.33%
High Blood Pressure: 1 person, 8.33%
Heavy Or Prolong Menstrual Bleeding: 1 person, 8.33%
Excessive Or Unwanted Hair In Women: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Aciphex and have Hypercoagulation?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Aciphex:

Aciphex (25,301 reports)

Browse all side effects of Aciphex:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hypercoagulation:

Hypercoagulation (428 drugs)

Browse all the conditions that are associated with Hypercoagulation:

Hypercoagulation (533 conditions)

Drugs similar to Aciphex and Hypercoagulation :

How the study uses the data?

The study uses data from the FDA. It is based on rabeprazole sodium (the active ingredients of Aciphex) and Aciphex (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.