Aciphex and Pathological fracture - a phase IV clinical study of FDA data

Summary:

Pathological fracture is reported as a side effect among people who take Aciphex (rabeprazole sodium), especially for people who are female, 60+ old, also take Actonel, and have Osteoporosis.

The phase IV clinical study analyzes which people have Pathological fracture when taking Aciphex. It is created by eHealthMe based on reports of 24,594 people who have side effects when taking Aciphex from the FDA, and is updated regularly.

What is Aciphex?

Aciphex has active ingredients of rabeprazole sodium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 25,301 Aciphex users. Check the latest studies of Aciphex.

What is Pathological fracture?

Pathological fracture (broken bone caused by disease) is found to be associated with 833 drugs and 542 conditions by eHealthMe. Check the latest studies of Pathological fracture.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

24,594 people reported to have side effects when taking Aciphex.
Among them, 29 people (0.12%) have Pathological fracture.

$Could Aciphex cause Pathological fracture?$

Among these 29 people:

What is the gender of people who have Pathological fracture when taking Aciphex? *

female: 79.31 %
male: 20.69 %

What is the age of people who have Pathological fracture when taking Aciphex? *

What are other drugs people take besides Aciphex? *

What are other side effects people have besides Pathological fracture? *

Joint Pain: 20 people, 68.97%
Femur Fracture: 17 people, 58.62%
Pain: 17 people, 58.62%
Fall: 16 people, 55.17%
Broken Bone: 15 people, 51.72%
Pain In Extremity: 11 people, 37.93%
Fracture Displacement: 11 people, 37.93%
Bone Disorder: 11 people, 37.93%
Groin Pain: 10 people, 34.48%
Osteonecrosis Of Jaw (death of bone of jaw): 10 people, 34.48%

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 16 people, 55.17%
Metastases To Bone (cancer spreads to bone): 3 people, 10.34%
Breast Cancer Metastatic: 3 people, 10.34%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 6.90%
Headache (pain in head): 1 person, 3.45%
Breast Cancer: 1 person, 3.45%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 1 person, 3.45%
Gastric Disorder (disease of stomach): 1 person, 3.45%
Gastric Ulcer (stomach ulcer): 1 person, 3.45%
Gynecomastia (enlargement of the gland tissue of the male breast): 1 person, 3.45%

* Approximation only. Some reports may have incomplete information.

Do you take Aciphex and have Pathological fracture?

- Check whether Pathological fracture is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Aciphex:

Aciphex (25,301 reports)

Browse all side effects of Aciphex:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Pathological fracture:

Pathological fracture (833 drugs)

Browse all the conditions that are associated with Pathological fracture:

Pathological fracture (542 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on rabeprazole sodium (the active ingredients of Aciphex) and Aciphex (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.