Actemra and Acute hepatic failure - a phase IV clinical study of FDA data

Summary:

Acute hepatic failure is reported as a side effect among people who take Actemra (tocilizumab), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Prednisone, and have Castleman's disease.

The phase IV clinical study analyzes which people have Acute hepatic failure when taking Actemra. It is created by eHealthMe based on reports of 102,551 people who have side effects when taking Actemra from the FDA, and is updated regularly.

What is Actemra?

Actemra has active ingredients of tocilizumab. It is often used in rheumatoid arthritis. eHealthMe is studying from 102,759 Actemra users. Check the latest studies of Actemra.

What is Acute hepatic failure?

Acute hepatic failure is found to be associated with 710 drugs and 1,180 conditions by eHealthMe. Check the latest studies of Acute hepatic failure.

On Jul, 14, 2026

102,551 people reported to have side effects when taking Actemra.
Among them, 14 people (0.01%) have Acute hepatic failure.

Could Actemra cause Acute hepatic failure?

Among these 14 people:

How long have people been on Actemra when they have Acute hepatic failure? *

What is the gender of people who have Acute hepatic failure when taking Actemra? *

female: 50 %
male: 50 %

What is the age of people who have Acute hepatic failure when taking Actemra? *

What are other drugs people take besides Actemra? *

Valacyclovir Hydrochloride: 3 people, 21.43%
Solu-Medrol: 3 people, 21.43%
Prednisone: 3 people, 21.43%
Maxipime: 2 people, 14.29%
Rituxan: 2 people, 14.29%
Zosyn: 1 person, 7.14%
Effexor: 1 person, 7.14%
Losartan: 1 person, 7.14%
Isovue-300: 1 person, 7.14%
Fluconazole: 1 person, 7.14%

What are other side effects people have besides Acute hepatic failure? *

Multi-Organ Failure (multisystem organ failure): 5 people, 35.71%
Sepsis (a severe blood infection that can lead to organ failure and death): 4 people, 28.57%
Acute Kidney Failure: 2 people, 14.29%
Anaemia (lack of blood): 2 people, 14.29%
Splenomegaly (enlargement of spleen): 2 people, 14.29%
Hepatic Failure (liver failure): 2 people, 14.29%
Septic Shock (shock due to blood infection): 2 people, 14.29%
Cytomegalovirus Viraemia (cytomegalo virus in blood stream): 2 people, 14.29%
Cholecystitis Acute (rapid infection of gallbladder): 2 people, 14.29%
Enterobacter Infection (infection caused by bacteria of the family enterobacteriaceae): 1 person, 7.14%

What are the existing conditions these people have? *

Juvenile Rheumatoid Arthritis (joint inflammation in children due to systemic disease): 3 people, 21.43%
Herpes Zoster: 3 people, 21.43%
Castleman's Disease (a disease of lymph nodes and related tissues): 3 people, 21.43%
Systemic Inflammatory Response Syndrome (an inflammatory state affecting the whole body, frequently a response of the immune system to infection): 2 people, 14.29%
Cytomegalovirus Viraemia (cytomegalo virus in blood stream): 2 people, 14.29%
Juvenile Arthritis (arthritis-related condition that develops in children or teenagers): 1 person, 7.14%
High Blood Pressure: 1 person, 7.14%
High Blood Cholesterol: 1 person, 7.14%
Diabetes: 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Actemra and have Acute hepatic failure?

- Check whether Acute hepatic failure is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Actemra:

Actemra (102,759 reports)

Browse all side effects of Actemra:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Acute hepatic failure:

Acute hepatic failure (710 drugs)

Browse all the conditions that are associated with Acute hepatic failure:

Acute hepatic failure (1,180 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on tocilizumab (the active ingredients of Actemra) and Actemra (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.