Acthar and Hoarseness or changing voice - a phase IV clinical study of FDA data

Summary:

Hoarseness or changing voice is reported as a side effect among people who take Acthar (corticotropin), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Humira, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Hoarseness or changing voice when taking Acthar. It is created by eHealthMe based on reports of 4,932 people who have side effects when taking Acthar from the FDA, and is updated regularly.

What is Acthar?

Acthar has active ingredients of corticotropin. eHealthMe is studying from 4,948 Acthar users. Check the latest studies of Acthar.

What is Hoarseness or changing voice?

Hoarseness or changing voice is found to be associated with 1,789 drugs and 2,661 conditions by eHealthMe. Check the latest studies of Hoarseness or changing voice.



On Jul, 09, 2026

4,932 people reported to have side effects when taking Acthar.
Among them, 18 people (0.36%) have Hoarseness or changing voice.

Could Acthar cause Hoarseness or changing voice?

Among these 18 people:

How long have people been on Acthar when they have Hoarseness or changing voice? *

  • < 1 month: 50 %
  • 1 - 6 months: 50 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Hoarseness or changing voice when taking Acthar? *

  • female: 70 %
  • male: 30 %

What is the age of people who have Hoarseness or changing voice when taking Acthar? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 16.67 %
  • 50-59: 16.67 %
  • 60+: 66.67 %

What are other drugs people take besides Acthar? *

  1. Orencia: 7 people, 38.89%
  2. Xeljanz: 7 people, 38.89%
  3. Humira: 7 people, 38.89%
  4. Rituxan: 3 people, 16.67%
  5. Imuran: 3 people, 16.67%
  6. Solu-Medrol: 3 people, 16.67%
  7. Lipitor: 2 people, 11.11%
  8. Nexium: 1 person, 5.56%
  9. Lyrica: 1 person, 5.56%
  10. Losartan: 1 person, 5.56%

What are other side effects people have besides Hoarseness or changing voice? *

  1. Drug Ineffective: 9 people, 50.00%
  2. Trigeminal Neuralgia (a painful condition of the nerve responsible for most facial sensation): 7 people, 38.89%
  3. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 7 people, 38.89%
  4. Secondary Progressive Multiple Sclerosis (a stage of ms which comes after relapsing remitting ms in many cases): 7 people, 38.89%
  5. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 7 people, 38.89%
  6. Movement - Uncoordinated: 7 people, 38.89%
  7. Weakness: 7 people, 38.89%
  8. Aseptic Necrosis (the death of bone tissue due to a lack of blood supply): 7 people, 38.89%
  9. Rashes (redness): 4 people, 22.22%
  10. Muscle Aches (muscle pain): 4 people, 22.22%

What are the existing conditions these people have? *

  1. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 8 people, 44.44%
  2. Dermatomyositis (inflammation of the skin and underlying muscle tissue, typically occurring as an autoimmune condition or associated with internal cancer): 3 people, 16.67%
  3. Vasculitis (inflammation of a blood vessel or blood vessels): 1 person, 5.56%
  4. Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 1 person, 5.56%
  5. Short-Bowel Syndrome (a condition in which the body cannot absorb enough fluids and nutrients because part of the small intestine is missing): 1 person, 5.56%
  6. Multiple Sclerosis Relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 5.56%
  7. Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking): 1 person, 5.56%
  8. Iga Nephropathy (kidney disease- condition prevents the kidneys from filtering waste): 1 person, 5.56%
  9. Glomerulonephritis Membranous (nephritis with inflammation of the capillary loops in the renal glomeruli): 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Acthar and have Hoarseness or changing voice?

- Check whether Hoarseness or changing voice is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously



Related studies:

Effectiveness of, long term effects of, and alternative drugs to Acthar:

Hoarseness or changing voice treatments and more:

How severe was Hoarseness or changing voice and when was it recovered:

Expand to all the drugs that have ingredients of corticotropin:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Acthar:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hoarseness or changing voice:

Browse all the conditions that are associated with Hoarseness or changing voice:


How the study uses the data?

The study uses data from the FDA. It is based on corticotropin (the active ingredients of Acthar) and Acthar (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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