Acthar and Injection site induration - a phase IV clinical study of FDA data

Summary:

Injection site induration is reported as a side effect among people who take Acthar (corticotropin), especially for people who are female, 30-39 old, have been taking the drug for < 1 month also take Benlysta, and have Systemic lupus erythematosus.

The phase IV clinical study analyzes which people have Injection site induration when taking Acthar. It is created by eHealthMe based on reports of 4,932 people who have side effects when taking Acthar from the FDA, and is updated regularly.

What is Acthar?

Acthar has active ingredients of corticotropin. eHealthMe is studying from 4,948 Acthar users. Check the latest studies of Acthar.

What is Injection site induration?

Injection site induration is found to be associated with 554 drugs and 627 conditions by eHealthMe. Check the latest studies of Injection site induration.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

4,932 people reported to have side effects when taking Acthar.
Among them, 12 people (0.24%) have Injection site induration.

Could Acthar cause Injection site induration?

Among these 12 people:

How long have people been on Acthar when they have Injection site induration? *

What is the gender of people who have Injection site induration when taking Acthar? *

female: 90.91 %
male: 9.09 %

What is the age of people who have Injection site induration when taking Acthar? *

What are other drugs people take besides Acthar? *

Benlysta: 2 people, 16.67%
Vitamin D: 1 person, 8.33%
Vitamin B12: 1 person, 8.33%
Tysabri: 1 person, 8.33%
Sulfamethoxazole And Trimethoprim: 1 person, 8.33%
Spironolactone: 1 person, 8.33%
Prednisone: 1 person, 8.33%
Potassium: 1 person, 8.33%
Plaquenil: 1 person, 8.33%
Multivitamin: 1 person, 8.33%

What are other side effects people have besides Injection site induration? *

Injection Site Bruising: 6 people, 50.00%
Injection Site Pruritus (severe itching at injection site): 6 people, 50.00%
Injection Site Pain: 4 people, 33.33%
Injection Site Mass: 2 people, 16.67%
Peripheral Swelling: 2 people, 16.67%
Injection Site Reaction: 2 people, 16.67%
Injection Site Swelling: 2 people, 16.67%
Injection Site Erythema (redness at injection site): 2 people, 16.67%
Dyspnea (difficult or laboured breathing): 2 people, 16.67%
Dizziness: 1 person, 8.33%

What are the existing conditions these people have? *

Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 4 people, 33.33%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 16.67%
Polymyositis (inflammatory muscle disease that causes weakness of the skeletal muscles): 2 people, 16.67%
Thrombocytopenia (decrease of platelets in blood): 1 person, 8.33%
Sarcoidosis (an inflammatory disease that affects multiple organs in the body, but mostly the lungs and lymph glands): 1 person, 8.33%
Pulmonary Sarcoidosis (growth of tiny collections of inflammatory cells in lungs): 1 person, 8.33%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 1 person, 8.33%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 8.33%
Focal Segmental Glomerulosclerosis (scar tissue that forms in parts of the kidney called glomeruli): 1 person, 8.33%
Dermatomyositis (inflammation of the skin and underlying muscle tissue, typically occurring as an autoimmune condition or associated with internal cancer): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Acthar and have Injection site induration?

- Check whether Injection site induration is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Acthar:

Acthar (4,948 reports)

Browse all side effects of Acthar:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Injection site induration:

Injection site induration (554 drugs)

Browse all the conditions that are associated with Injection site induration:

Injection site induration (627 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on corticotropin (the active ingredients of Acthar) and Acthar (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.