Actifed and Heart attack - a phase IV clinical study of FDA data

Summary:

Heart attack is reported as a side effect among people who take Actifed (pseudoephedrine hydrochloride; triprolidine hydrochloride), especially for people who are male, 30-39 old, have been taking the drug for < 1 month also take Tylenol, and have Enlarged heart.

The phase IV clinical study analyzes which people have Heart attack when taking Actifed. It is created by eHealthMe based on reports of 991 people who have side effects when taking Actifed from the FDA, and is updated regularly.

What is Actifed?

Actifed has active ingredients of pseudoephedrine hydrochloride; triprolidine hydrochloride. It is often used in allergies. eHealthMe is studying from 1,091 Actifed users. Check the latest studies of Actifed.

What is Heart attack?

Heart attack is found to be associated with 2,537 drugs and 3,272 conditions by eHealthMe. Check the latest studies of Heart attack.

On Jan, 20, 2026

991 people reported to have side effects when taking Actifed.
Among them, 14 people (1.41%) have Heart attack.

Among these 14 people:

How long have people been on Actifed when they have Heart attack? *

What is the gender of people who have Heart attack when taking Actifed? *

female: 18.18 %
male: 81.82 %

What is the age of people who have Heart attack when taking Actifed? *

What are other drugs people take besides Actifed? *

What are other side effects people have besides Heart attack? *

Death: 7 people, 50.00%
Chest Pain: 6 people, 42.86%
Abdominal Pain Upper: 5 people, 35.71%
Dyspnea (difficult or laboured breathing): 5 people, 35.71%
High Blood Pressure: 5 people, 35.71%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 5 people, 35.71%
Stomach Discomfort (pain in abdomen): 4 people, 28.57%
Epigastric Discomfort: 4 people, 28.57%
Coronary Heart Disease (narrowing or blockage of the coronary arteries): 4 people, 28.57%
Injury: 4 people, 28.57%

What are the existing conditions these people have? *

Weight Loss: 3 people, 21.43%
High Blood Pressure: 3 people, 21.43%
Enlarged Heart: 3 people, 21.43%
Rhinitis (a medical term for irritation and inflammation of the mucous membrane inside the nose): 1 person, 7.14%
Pain: 1 person, 7.14%
Osteopenia (a condition where bone mineral density is lower than normal): 1 person, 7.14%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 1 person, 7.14%
Hypersensitivity: 1 person, 7.14%
Gastric Disorder (disease of stomach): 1 person, 7.14%
Fluid Retention (an abnormal accumulation of fluid in the blood): 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Actifed and have Heart attack?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Actifed:

Actifed (1,091 reports)

Heart attack treatments and more:

Heart attack (266,139 reports)

How severe was Heart attack and when was it recovered:

Heart attack in Actifed

Expand to all the drugs that have ingredients of pseudoephedrine hydrochloride; triprolidine hydrochloride:

Heart attack and drugs with ingredients of pseudoephedrine hydrochloride; triprolidine hydrochloride (14 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Actifed:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Heart attack:

Heart attack (2,537 drugs)

Browse all the conditions that are associated with Heart attack:

Heart attack (3,272 conditions)

Drugs similar to Actifed and Heart attack :

How the study uses the data?

The study uses data from the FDA. It is based on pseudoephedrine hydrochloride; triprolidine hydrochloride (the active ingredients of Actifed) and Actifed (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.